An Efficient Synthesis of Dutasteride: Utilizing Benzoyl Group as Novel Lactamic Protecting Group

    January 2017 in “ Rasayan journal of Chemistry ”
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    TLDR Researchers created a new, efficient way to make Dutasteride, a hair loss and prostate drug, with high purity using a benzoyl group.
    In 2017, researchers developed an efficient and scalable synthesis method for Dutasteride, a medication for hair loss and prostate enlargement, using a benzoyl group as a novel protecting group. This method allowed for the large-scale commercial production of Dutasteride with a final purity of 99.9%. The synthesis involved crystallization from methanol to purify intermediates and used inexpensive reagents for deprotection, yielding high purity Dutasteride with minimal impurities. The study demonstrated that this new synthesis route is industrially viable and simplifies the production process, as confirmed by HPLC analysis. The research was supported by Macleods Pharmaceuticals Limited and the Analytical Research Department.
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