Case Report: NUDT15 Polymorphism and Severe Azathioprine-Induced Myelosuppression in a Young Chinese Female with Systemic Lupus Erythematosus: A Case Analysis and Literature Review

    May 2023 in “ Frontiers in Pharmacology ”
    Juan Gu, Yupei Lin, Yuhe Wang
    Studysummary In this study, a case of a young Chinese female with a specific NUDT15 genetic variant experienced severe azathioprine-induced myelosuppression and alopecia while treating systemic lupus erythematosus, highlighting the need for routine blood monitoring during treatment to manage AZA intolerance associated with genetic factors.
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    Research cited in this study 3

    1. Azathioprine-Induced Severe Myelosuppression Accompanied by Massive Hair Loss and Painful Oral Ulcer in an Autoimmune Hepatitis Patient with NUDT15 Minor Variant: A Case Report Clinical Case Reports · 2021
    2. NUDT15 Polymorphism Explains Serious Toxicity to Azathioprine in Indian Patients With Chronic Immune Thrombocytopenia and Autoimmune Hemolytic Anemia: A Case Series Drug metabolism and drug interactions · 2020
    3. Azathioprine-Induced Alopecia And Leukopenia Associated With NUDT15 Polymorphisms Journal of the European Academy of Dermatology and Venereology · 2018