TLDR Thiopurines help treat IBD but require genetic testing to avoid side effects.
The document reviewed the role of thiopurines in treating inflammatory bowel diseases (IBD), emphasizing their effectiveness in maintaining remission and the importance of genetic testing to minimize adverse effects. Thiopurines, such as azathioprine and 6-mercaptopurine, were effective but posed risks like leukopenia and alopecia, particularly in individuals with NUDT15 polymorphisms. Combination therapy with biological agents showed improved outcomes. The review highlighted the need for personalized medicine approaches, including pharmacogenetic testing, to optimize treatment and minimize side effects, and called for further research to balance the benefits and risks of thiopurines.
86 citations,
November 2015 in “Journal of Gastroenterology” The NUDT15 R139C variant causes thiopurine-induced leukocytopenia through a different mechanism than previously thought in Japanese patients with inflammatory bowel disease.
51 citations,
August 2015 in “Cochrane library” Methotrexate is not proven to maintain remission in ulcerative colitis.
April 2017 in “Childhood Kidney Diseases” Azathioprine can cause severe blood issues and hair loss, needing careful monitoring and possible discontinuation.
3 citations,
August 2021 in “Clinical Case Reports” Genetic testing is crucial before giving azathioprine to avoid severe side effects.
3 citations,
April 2023 in “Veterinary sciences” Researchers found genes that may explain why some pigs grow winter hair, which could help breed cold-resistant pigs.
86 citations,
November 2015 in “Journal of Gastroenterology” The NUDT15 R139C variant causes thiopurine-induced leukocytopenia through a different mechanism than previously thought in Japanese patients with inflammatory bowel disease.
60 citations,
September 2013 in “Alimentary Pharmacology & Therapeutics” Immunosuppressive and anti-TNF therapies in IBD patients can increase the risk of skin cancer and cause various skin issues.
