NUDT15 R139C-Related Thiopurine Leukocytopenia Is Mediated by 6-Thioguanine Nucleotide-Independent Mechanism in Japanese Patients with Inflammatory Bowel Disease

November 2015 in “ Journal of Gastroenterology ”

Ayumi Asada, Atsushi Nishida, Makoto Shioya, Hirotsugu Imaeda, Osamu Inatomi, Shigeki Bamba, Katsuyuki Kito, Mitsushige Sugimoto, Akira Andoh

Studysummary This study reported that the NUDT15 R139C genetic variant was significantly associated with thiopurine-induced leukocytopenia in Japanese inflammatory bowel disease patients, independent of 6-thioguanine nucleotide levels. Our plain-language summary of this paper — not a Tressless recommendation.

The study concluded that the NUDT15 R139C variant caused thiopurine-induced leukocytopenia through a mechanism independent of 6-thioguanine nucleotide levels in Japanese patients with inflammatory bowel disease. This finding suggested that the adverse effects of thiopurine drugs in these patients were not solely due to the accumulation of 6-thioguanine nucleotides, indicating the need for alternative monitoring and management strategies for those carrying the NUDT15 R139C variant.

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22 citations , July 2015 in “PloS one”

This study found that Foxp1, a transcriptional factor, plays a key role in regulating hair follicle stem cell proliferation by modulating oxidative stress and the cell cycle during hair growth phases.