Azathioprine-Induced Alopecia And Leukopenia Associated With NUDT15 Polymorphisms

    July 2018 in “ Journal of the European Academy of Dermatology and Venereology ”
    Ayano Fukushima‐Nomura, Yasushi Kurihara, Masataka Saito, Ayako Fukushima, Yukako Shintani, Rie Shiiyama, Satoshi Toshima, Aki Kamata, Jun Yamagami, Takeru Funakoshi, Kaori Kameyama, Masayuki Amagai, Akiharu Kubo, Noriko Umegaki‐Arao
    TLDR Certain genetic variations can make people more likely to experience hair loss and low white blood cell count from azathioprine.
    The letter to the editor discussed the association between azathioprine-induced alopecia and leukopenia with NUDT15 polymorphisms. The authors from the Department of Dermatology at Keio University School of Medicine highlighted that individuals with certain NUDT15 genetic variations were more susceptible to these adverse effects when treated with azathioprine. This finding underscored the importance of genetic screening for NUDT15 polymorphisms to predict and prevent these side effects in patients undergoing azathioprine therapy.
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