Azathioprine-Induced Alopecia And Leukopenia Associated With NUDT15 Polymorphisms

April 2018 in “ Journal of the European Academy of Dermatology and Venereology ”

Ayano Fukushima‐Nomura, Yasushi Kurihara, Masataka Saito, Ayako Fukushima, Yukako Shintani, Rie Shiiyama, Satoshi Toshima, Aki Kamata, Jun Yamagami, Takeru Funakoshi, Kaori Kameyama, Masayuki Amagai, Akiharu Kubo, Noriko Umegaki‐Arao

azathioprine alopecia leukopenia NUDT15 polymorphisms genetic screening

TLDR Certain genetic variations can make people more likely to experience hair loss and low white blood cell count from azathioprine.

The document discussed azathioprine-induced alopecia and leukopenia, which were associated with NUDT15 polymorphisms. The study highlighted that individuals with certain NUDT15 genetic variations were more susceptible to these adverse effects when treated with azathioprine. This finding underscored the importance of genetic screening before administering azathioprine to predict and prevent these side effects. The research was conducted by a team from the Department of Dermatology at Keio University School of Medicine in Tokyo, Japan.

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