TLDR A woman experienced severe side effects from a drug due to a specific genetic variation, suggesting genetic testing could prevent such risks.
This case report described a 37-year-old woman who experienced azathioprine-induced agranulocytosis and severe alopecia after a kidney transplant, which was linked to a NUDT15 polymorphism (rs116855232, p.Arg139Cys). The patient had stable renal function post-transplant and was on a triple-immunosuppressant regimen. The NUDT15 polymorphism was identified through genome-wide correlation analysis, marking this as the first reported case of such adverse effects in a kidney transplant patient with this genetic variant.
86 citations,
November 2015 in “Journal of Gastroenterology” The NUDT15 R139C variant causes thiopurine-induced leukocytopenia through a different mechanism than previously thought in Japanese patients with inflammatory bowel disease.
3 citations,
August 2021 in “Clinical Case Reports” Genetic testing is crucial before giving azathioprine to avoid severe side effects.
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January 2016 in “Springer eBooks” Understanding drug interactions, side effects, and patient-specific factors is crucial for effective dermatological care.
1 citations,
January 2021 in “Journal of the Dermatology Nurses’ Association” The convention discussed various skin conditions and treatments, and highlighted the importance of vaccinations for patients on immune-altering medications.
May 2023 in “Frontiers in Endocrinology” Thyroid disease can cause skin, hair, and nail problems, and treating the thyroid condition often improves these symptoms.
