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Genetic screening for NUDT15 polymorphisms is crucial for patients taking azathioprine, especially in Asians.

Monitor for early signs of azathioprine toxicity and check blood counts regularly.

Thiopurines help treat IBD but require genetic testing to avoid side effects.

Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.

Personalized thiopurine dosing based on NUDT15 genotyping can improve long-term outcomes for ulcerative colitis and Crohn's disease patients.