A Case of Azathioprine Induced Severe Myelosuppression and Alopecia Totalis in IgA Nephropathy

    April 2017 in “ Childhood Kidney Diseases ”
    Jae Choon Kim, Ye Kyung Kim, Hyesun Hyun, Eujin Park, Hee Gyung Kang, Il Soo Ha, Hae Il Cheong
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    TLDR Azathioprine can cause severe blood issues and hair loss, needing careful monitoring and possible discontinuation.
    A 10-year-old boy with IgA nephropathy treated with azathioprine developed severe myelosuppression and alopecia totalis within 6 weeks. Despite dose reduction, his condition worsened, but normalized after discontinuing azathioprine and administering granulocyte colony-stimulating factor. This case highlighted the need for vigilance regarding azathioprine's side effects, suggesting that unusual hair loss might indicate a metabolic defect requiring drug discontinuation.
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