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This forum article in BMC Biology discusses evolving views on the concept of the stem cell niche, highlighting varied mechanisms and the need for better understanding of the niche's roles and functions.

This study found that mice lacking the 1αOHase enzyme, which is responsible for producing a key vitamin D metabolite, showed impaired epidermal differentiation and delayed recovery of skin barrier function after disruption.

This study found that cortisone reductase deficiency is caused by inactivating mutations in the H6PD gene, affecting cortisol metabolism by preventing 11β-HSD1 enzyme function.

This review explores the diverse roles and heterogeneity of fibroblasts across different organs, highlighting their potential involvement in both normal tissue functioning and fibrotic diseases, but reports no new experimental results.

This study found that mouse FLRG protein, a secreted glycoprotein, is expressed in certain tissues and plays a role distinct from follistatin during wound healing, suggesting different functions in vivo.

This review discusses various applications of CRISPR-based tools in cancer research, emphasizing their potential for investigating microRNA functions and developing microRNA-based therapies, despite challenges like off-target effects and delivery issues in using CRISPR/Cas9.

This article discusses melanocyte development from neural crest cells and reports no new experimental results; the authors suggest a broader range of functions for melanocytes than previously recognized.

This review examines emerging biomaterial strategies designed to support both neural regeneration and cutaneous wound healing, emphasizing their potential to improve sensory function through mechanisms like axonal regrowth and vascular network formation, while noting the need for standardized assessments and clinically translatable designs.

This review summarizes the role of G-protein-coupled receptors in wound healing and reports no new clinical results, highlighting their importance in signaling pathways and recent discoveries in their functions.

In this report, a case of a large primary extradural solitary fibrous tumor in the sacrum of a 31-year-old woman is detailed, where surgical treatment led to remission and improved functionality, despite the patient opting out of adjuvant radiotherapy to preserve fertility potential.

This study highlights the role of innate immunity and purinergic signaling in regulating hematopoiesis and hematopoietic stem/progenitor cell specification. The researchers observed that these ancient pathways operate both paracrinally and autocrinally within HSPCs, maintaining their developmental function throughout evolution.

This study suggests that hair follicle mesenchymal stem cells may alleviate small intestinal ischaemia-reperfusion injury in rats by promoting angiogenesis, reducing apoptosis, and protecting intestinal mucosal function.

This overview examines the biology, origin, structure, and function of various cells and structures, such as the blood-retinal barrier and Merkel cells, and discusses their roles in disease pathogenesis, along with recent findings related to the lymph nodes' paracortex.

This study reviews the embryological origins, anatomical and histological structure, and key functions of the skin, emphasizing its protective, sensory, and regulatory roles, as well as the social and psychological impacts of post-lesion changes.

This chapter reviews the presence and roles of stem cells in various body systems, focusing on their lifelong function in animals and humans, and reports no new experimental findings.

This study reported that interdisciplinary treatment, combining surgical and rehabilitation methods, led to satisfactory outcomes for patients with extensive facial skull injuries. The authors emphasized the importance of teamwork between surgeons and physiotherapists to minimize complications and enhance recovery, restoring function, aesthetics, and physical fitness.

This study constructed a comprehensive atlas of prenatal human skin, revealing that innate immune cells, such as macrophages, play a crucial role in skin morphogenesis by interacting with non-immune cells, influencing hair follicle formation and angiogenesis beyond their traditional immune functions.

Neonatal neurosteroid levels affect adult brain function and behavior.

This study found that epidermal VEGF is crucial for maintaining skin barrier function in mice and may help explain psoriasis development following skin trauma due to its effects on angiogenesis and hyperplasia.

This review discusses the multifaceted roles of hair follicles in skin health, including potential contributions to skin neoplasias, and reports no new results.

This review synthesizes both traditional and emerging molecular mechanisms of tissue remodeling across different organs, aiming to establish a theoretical basis for precision interventions in pathological conditions, according to the authors.

This review outlines the functional anatomy, pathology, and molecular mechanisms of androgenetic alopecia, emphasizing the need for multi-omics approaches to better understand this condition's biology.

This review discusses the immune functions of porcine skin and proposes a classification of dendritic cell subsets based on similarities to human skin, but it reports no new clinical results.

This study found that thyroid-stimulating hormone receptors are functionally expressed in various skin cells, implying potential physiological and pathological roles in skin, especially in conditions like autoimmune diseases.

This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.

This study suggests that enhancing glycolysis in MSCs may improve their immune functions and therapeutic potential, although more evidence is needed to understand the direct metabolic mechanisms involved.

This review discusses newly identified non-Edg family lysophosphatidic acid receptors, detailing their roles in vascular development, platelet activation, and hair growth, and reports no clinical results.

Hormones and signaling pathways control sebaceous gland function and could help treat acne.

This review discusses various in vitro and in vivo models for studying hair follicle function, noting their potential in developing new treatments for hair disorders but reports no new results.

This study found that loliolide enhanced hair growth-related functions in 3D dermal papilla spheroids by activating AKT/β-catenin signaling pathways, with increased expression of related growth factors and genes.