GPCRs as Key Regulators in Wound Healing

April 2026 in “ Frontiers in Cell and Developmental Biology ”

Haidi Chen, Kun Zheng, Yue Xiao, Xun Feng, Chang Zhang, Ting Zhang, Feng Luo, Huangyu Chuan, Huaping Zheng, Cheng Deng, Wei Li

G-protein-coupled receptors GPCRs Hedgehog-GLI Hippo-YAP1 Wnt/β-catenin epidermal cell proliferation epidermal cell differentiation agonists antagonists immune cell recruitment inflammatory mediator production

Studysummary This review summarizes the role of G-protein-coupled receptors in wound healing and reports no new clinical results, highlighting their importance in signaling pathways and recent discoveries in their functions.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

G-protein-coupled receptors (GPCRs) are crucial in the wound healing process, influencing immune cell recruitment and signaling pathways like Hedgehog-GLI, Hippo-YAP1, and Wnt/β-catenin, which are involved in epidermal cell proliferation and differentiation. By modifying GPCR activity with agonists or antagonists, it is possible to impact immune cell infiltration, inflammatory mediator production, and the rate of wound healing. This review discusses the fundamental mechanisms of GPCR signaling in wound healing and recent discoveries about their roles and functions.

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