Engineering Strategies to Enhance the Research Progress of Mesenchymal Stem Cells in Wound Healing
July 2025
in “
Stem Cell Research & Therapy
”
TLDR Engineering strategies improve stem cells' ability to heal wounds effectively.
The document explores engineering strategies to enhance the effectiveness of mesenchymal stem cells (MSCs) in wound healing, addressing challenges like poor survival in harsh environments. Strategies such as biomaterials, cytokine and hypoxic preconditioning, and genetic modification are discussed to improve MSC resilience and therapeutic efficacy. Scaffolds and hydrogels mimic the extracellular matrix, supporting MSC survival and function, while MSC-derived exosomes offer a promising cell-free therapeutic approach. Despite advancements, challenges remain in optimizing delivery and retention for clinical applications. Future research should focus on combination strategies and personalized treatments to improve trauma healing and patient outcomes.
