Engineering Strategies to Enhance the Research Progress of Mesenchymal Stem Cells in Wound Healing

July 2025 in “ Stem Cell Research & Therapy ”

Dawei Wang, Ao Chen, Yuan Fang, Chuanxue Ma, Yafei Lu, Chungen Zhou, Qizhi Liu, Bin Jiang

mesenchymal stem cells wound healing self-renewal tissue repair angiogenesis immunomodulation gene modification preconditioning biomaterial scaffolds hydrogels proliferation migration therapeutic potential scar formation clinical applications

Studysummary This review summarizes the mechanisms of mesenchymal stem cell-mediated wound healing and highlights engineering strategies that enhance therapeutic outcomes, but it reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.

The document explores engineering strategies to enhance the effectiveness of mesenchymal stem cells (MSCs) in wound healing, addressing challenges like poor survival in harsh environments. Strategies such as biomaterials, cytokine and hypoxic preconditioning, and genetic modification are discussed to improve MSC resilience and therapeutic efficacy. Scaffolds and hydrogels mimic the extracellular matrix, supporting MSC survival and function, while MSC-derived exosomes offer a promising cell-free therapeutic approach. Despite advancements, challenges remain in optimizing delivery and retention for clinical applications. Future research should focus on combination strategies and personalized treatments to improve trauma healing and patient outcomes.

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research The Role and Prospects of Mesenchymal Stem Cells in Skin Repair and Regeneration

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research Bilayer Silk Fibroin/Sodium Alginate Scaffold Delivered Human Umbilical Cord Mesenchymal Stem Cells to Enhance Skin Scarless Healing and Hair Follicle Regeneration with the IRE1/XBP1 Pathway Inhibition

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This study found that a silk fibroin/sodium alginate scaffold effectively delivers human umbilical mesenchymal stem cells to promote scarless wound healing and hair follicle regeneration in vivo by inducing specific cellular processes and mitigating endoplasmic reticulum stress.

research Mesenchymal Stem Cells Pretreated With Collagen Promote Skin Wound-Healing

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research Wound Healing: Cellular Mechanisms and Pathological Outcomes

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research Fibrous Scaffolds Potentiate the Paracrine Function of Mesenchymal Stem Cells: A New Dimension in Cell-Material Interaction

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This study found that adipose-derived mesenchymal stem cells produced more anti-inflammatory and pro-angiogenic cytokines on electrospun scaffolds, which enhanced wound healing and macrophage activity in a rat model.