July 2026 in “npj Regenerative Medicine” This study found that applying Laponite clay gels to skin wounds in mice did not speed up wound closure but significantly improved healing quality compared to phosphate-buffered saline or alginate treatments, with benefits such as enhanced re-epithelialization and hair follicle stimulation near wounds.
November 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review examined natural hair gels, incorporating an experimental polyherbal gel, and reported that these formulations possess multifunctional benefits for hair health, while also highlighting the importance of product safety and potential for innovative delivery systems.
10 citations
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July 2023 in “Pharmaceuticals” This study explored the wound healing potential of a natural marine soft coral-derived nanoparticle-based gel in a diabetic excision wound model, finding it effectively regulates proinflammatory cytokines and inhibits enzymes related to wound healing.
4 citations
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January 2010 in “International journal of trichology” Bexarotene gel shows promise as a new treatment for alopecia areata.
March 2025 in “Journal of Investigative Dermatology”
February 2024 in “International Journal For Multidisciplinary Research” This review examines the advances in nanostructured lipid carriers for treating hyperpigmentation but presents no new clinical results; the authors highlight their potential benefits and applications.
This study found that nanostructured lipid carriers enabled effective follicular delivery and accumulation of anti-hair loss drugs like dutasteride in mice, suggesting potential for reduced dosage frequency.
January 2019 in “Springer eBooks” PLGA nanospheres in cosmetics improve skin and hair treatment effectiveness.
In this case series, researchers reported an unexpectedly rapid and positive response to a topical, hydrogel-based botanical treatment for androgenetic alopecia in both male and female volunteers, achieving significant improvement in hair loss within 90 days instead of the planned 270 days.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study developed a multipurpose herbal gel formulation that enhances hair manageability, provides antimicrobial benefits, and supports skin care. The gel is non-irritating, leaves hair soft, and imparts a glow to the skin while being cost-effective.
This study found that mouse type II spiral ganglion neurites in vitro avoided laminin and high concentrations of fibronectin, indicating both can guide neurite paths differently than type I neurites.
4 citations
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January 2016 in “Journal of analytical & bioanalytical techniques” This study evaluated a hair growth gel with Hibiscus rosa sinensis, Eclipta alba, and Solanum nigrum extracts, demonstrating consistent homogeneity, 5 α-reductase inhibitory activity, and no skin irritation.
62 citations
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November 2022 in “Acta Pharmaceutica Sinica B” This study reported that an injectable hydrogel based on platelet-rich plasma and laponite improved wound healing in diabetic and normal rats by enhancing angiogenesis and macrophage polarization.
April 2025 in “Clinical and Translational Discovery” In this study, ketoconazole-loaded transferosomes were developed and demonstrated improved hair growth compared to a commercially available ketoconazole product, with the formulation showing enhanced drug penetration and minimal skin irritation in vivo.
1 citations
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December 2020 in “Medical lasers” The laser therapy device effectively increased hair growth in people with androgenetic alopecia.
2 citations
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January 2025 in “Naunyn-Schmiedeberg s Archives of Pharmacology” Nanostructured lipid carriers can improve alopecia treatment by enhancing drug delivery and promoting hair growth.
31 citations
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September 2019 in “Acta Pharmacologica Sinica”
July 2018 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that finasteride delivered through a nano-transferosomal gel showed improved penetration through skin layers compared to a conventional gel, suggesting a potential alternative for oral administration.
8 citations
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January 2025 in “Gels” This study developed cilostazol-loaded formulations for nose-to-brain delivery, finding that these formulations improved cilostazol's bioavailability by enhancing solubility, absorption, and permeability, achieving nearly 100% drug release in vitro within 2 hours.
January 2018 in “journal of applied pharmaceutical science” This study found that biomimetic peptides may enhance the expression of growth factors in the hair follicles of patients experiencing telogen effluvium.
October 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study investigated NNAT expression in embryonic and postnatal rat tissues, finding its localization in both undifferentiated and differentiated cells across tissues such as the pancreas, tongue, and testis.
April 2009 in “The FASEB Journal” This study demonstrated that a keratin gel promotes nerve regeneration across critical defects in rabbit models, showing improved nerve conduction and muscle action potential compared to control treatments.
This study found that liquid nitrogen cryotherapy resulted in good responses in 33% of patients with recalcitrant alopecia areata, although nearly 30% showed no response.
November 2023 in “Journal of medical and health studies” In this study, combining low-level laser therapy with microneedling showed statistically significant improvement in hair growth for three adult patients with androgenetic alopecia over three months, suggesting it may be a promising management approach.
4 citations
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November 2024 in “Nano Biomedicine and Engineering” This study reported that silver nanoparticles synthesized from jackfruit leaf extract demonstrated broad-spectrum antimicrobial properties, with a formulated gel showing greater efficacy against E. coli compared to a commercial silver nitrate product.
March 2025 in “Frontiers in Pharmacology” This study developed a hydrogel dressing incorporating angelica polysaccharides, demonstrating enhanced wound healing properties in a mouse model by promoting rapid hemostasis, tissue healing, and new blood vessel formation compared to Tegaderm™ film.
4 citations
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March 2019 in “Journal of Pure and Applied Microbiology” This study investigated the anti-inflammatory effects of a 940nm diode laser in Wistar rats with carrageenan-induced arthritis and found that a 74J/cm² energy density significantly reduced edema and restored function, whereas 171J/cm² neared thermal exposure limits for the skin.
6 citations
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August 2020 in “International Research Journal on Advanced Science Hub” In this study, researchers developed a niosomal gel system for transdermal delivery of testosterone, reporting strong penetrative capability, good spreadability, and a promising in vitro drug release profile, suggesting it may be an effective alternative for reducing the side effects of steroid treatments.
September 2025 in “The health sciences AUS.” This review discusses the efficacy and safety of intralesional triamcinolone acetonide for treating acne keloidalis nuchae, highlighting its significant effectiveness with rare side effects when used properly.
October 2024 in “Journal of Advanced Pharmaceutical Technology amp Research” This study found that nanoparticulate trigonelline formulations significantly improved hair length and density in rats with induced alopecia compared to controls and commercial hair oil, though it was not more effective than minoxidil after 30 days.