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GlossaryATAC-seq (ATAC sequencing)

technique identifies open chromatin regions to study gene regulation

ATAC-seq, or Assay for Transposase-Accessible Chromatin using sequencing, is a technique used to study the accessibility of chromatin, which is the material that makes up chromosomes. By identifying regions of DNA that are open and accessible, ATAC-seq helps researchers understand which parts of the genome are active and potentially involved in gene regulation. This method is valuable for studying gene expression patterns in various biological contexts, including development, disease, and cellular responses.

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Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Reveal Etiological Insights Into Genetic Risk for Hair and Skin Disease

research Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Reveal Etiological Insights Into Genetic Risk for Hair and Skin Disease

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

The research provided new insights into the genetic factors contributing to hair loss and skin conditions by analyzing individual cells from the human scalp.

research Single Cell Analysis of Transcriptome and Open Chromatin Reveals the Dynamics of Hair Follicle Stem Cell Aging

3 citations, July 2023 in “Frontiers in Aging”

Hair follicle stem cells change states with age, affecting hair growth and aging.

Transcriptome Analyses of Reprogrammed Feather/Scale Chimeric Explants Revealed Co-Expressed Epithelial Gene Networks During Organ Specification

research Transcriptome Analyses of Reprogrammed Feather/Scale Chimeric Explants Revealed Co-Expressed Epithelial Gene Networks During Organ Specification

7 citations, October 2018 in “BMC genomics”

Key genes can rewire networks, changing skin appendage types.

research Molecular Heterogeneity of Quiescent Melanocyte Stem Cells Revealed by Single-Cell RNA-Sequencing

April 2024 in “Pigment cell & melanoma research”

Different types of resting melanocyte stem cells have unique characteristics and vary in their potential to become other cells.

research Temporal Layering of Signaling Effectors Drives Chromatin Remodeling During Hair Follicle Stem Cell Lineage Progression

85 citations, January 2018 in “Cell stem cell”

Different signals work together to change gene activity and guide hair follicle stem cells to become specific cell types.

research Regulation of Adipocyte Dedifferentiation at the Skin Wound Edge

November 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Adipocytes can change into fibroblast-like cells to help with wound healing.

research Wound Healing: A Cellular Perspective

1160 citations, November 2018 in “Physiological Reviews”

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

research Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

174 citations, November 2016 in “Cell stem cell”

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

research Aging, Alopecia, and Stem Cells

42 citations, February 2016 in “Science”

The document concludes that both internal stem cell factors and external influences like the environment and hormones affect hair loss and aging, with potential treatments focusing on these areas.

research Stem Cells Tightly Regulate Dead Cell Clearance to Maintain Tissue Fitness

2 citations, May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Stem cells help remove dead cells to keep tissues healthy by balancing cell replacement and clearance.

research Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium

181 citations, February 2019 in “Cell”

Innate lymphoid cells help control skin bacteria by regulating sebaceous glands.

research Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease

9 citations, March 2022 in “Frontiers in Immunology”

Foxp3+ Regulatory T Cells are important for immunity and tolerance, affect hair growth and wound healing, and their dysfunction can contribute to obesity-related diseases and other health issues.

research Meeting Report: 68th Montagna Symposium on the Biology of Skin 'Decoding Complex Skin Diseases: Integrating Genetics, Genomics, and Disease Biology'

June 2020 in “Journal of Investigative Dermatology”

The symposium highlighted the importance of genetics in understanding and treating complex skin diseases.

research Promotion of Hair Growth in Alopecia Areata by Topical Treatment of HDAC Inhibitors

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

HDAC inhibitors, like Vorinostat and Entinostat, can help regrow hair in alopecia areata.

research Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells

17 citations, June 2019 in “The journal of immunology/The Journal of immunology”

A specific DNA region is crucial for Foxn1 gene expression in thymus cells but not in hair follicles.

research The Pioneer Factor SOX9 Competes for Epigenetic Factors to Switch Stem Cell Fates

6 citations, July 2023 in “Nature cell biology”

SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.

research Predictive Modeling of Patient Response to JAK/STAT Inhibitors and Dynamic Patient-Matching

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Machine learning can predict how well patients with alopecia areata will respond to certain treatments.

research Skin Fibroblast Functional Heterogeneity in Health and Disease

1 citations, August 2023 in “The Journal of Pathology”

Different types of skin fibroblasts have unique roles in skin health and disease.

research Transcriptional Regulation of the Thymus Master Regulator Foxn1

6 citations, August 2022 in “Science immunology”

Foxn1 gene regulation is crucial for thymus development but not for hair growth.

$Dietary Vitamin A Impacts Refractory Telogen$

research Dietary Vitamin A Impacts Refractory Telogen

6 citations, February 2021 in “Frontiers in Cell and Developmental Biology”

Eating too much or too little vitamin A can cause hair loss.

DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

research DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

3 citations, January 2023 in “Science advances”

The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.

research Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing

128 citations, August 2020 in “Cell stem cell”

Dermal fibroblasts have adjustable roles in wound healing, with specific cells promoting regeneration or scar formation.

research Stem Cell Dynamics, Migration, and Plasticity During Wound Healing

211 citations, November 2018 in “Nature Cell Biology”

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

research New Insights Into Inflammatory Memory of Epidermal Stem Cells

2 citations, May 2023 in “Frontiers in immunology”

Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.

research States and Fates of Skin Fibroblasts Revealed Through Chromatin Accessibility

February 2022 in “Journal of Investigative Dermatology”

Newborn skin cells can change into wound-healing cells more easily than adult ones, which might explain why baby skin heals without scars. Understanding this could help treat chronic wounds and prevent scarring.

research Characterization of Ectomesenchyme as an Origin of Epidermal Stem Cells

April 2023 in “Journal of Investigative Dermatology”

Ectomesenchyme is a key source of skin stem cells.

Fibroblast Heterogeneity and Functions: Insights from Single-Cell Sequencing in Wound Healing, Breast Cancer, Ovarian Cancer, and Melanoma

research Fibroblast Heterogeneity and Functions: Insights from Single-Cell Sequencing in Wound Healing, Breast Cancer, Ovarian Cancer, and Melanoma

March 2024 in “Frontiers in genetics”

Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.

research Lineage Commitment of Dermal Fibroblast Progenitors Is Mediated by Chromatin De-repression

1 citations, March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Skin cell types develop when specific genes are turned on by removing certain chemical tags from DNA.

Trajectory of Human Induced Pluripotent Stem Cells Derived Neural Progenitor Cells Differentiation into Dermal Papilla-Like Cells and Their Characteristics

research Trajectory of Human Induced Pluripotent Stem Cells Derived Neural Progenitor Cells Differentiation into Dermal Papilla-Like Cells and Their Characteristics

August 2023 in “Scientific reports”

Human stem cells were turned into cells similar to those that help grow hair and showed potential for hair follicle formation.

research Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices

214 citations, April 2017 in “Cell”

Different small areas within hair follicles send specific signals that control what type of cells stem cells become.