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In this study, researchers analyzed 355 clinical trials from ClinicalTrials.gov, initiated by the end of 2025, to provide insights into the use of extracellular vesicles as circulating biomarkers or therapeutic interventions, highlighting current research priorities and future trends.

This review explores the potential roles of extracellular vesicles in various medical fields, emphasizing their promise but noting the need for standardization and clinical testing before widespread application.

This review discusses the dual role of extracellular vesicles in Alzheimer's disease, highlighting their potential in both exacerbating and alleviating the condition, and emphasizes the need for advanced technologies to enhance diagnosis and treatment.

This review discusses the potential of biomimetic synthetic vesicles to advance precision diagnostics and medicine by combining the beneficial properties of naturally occurring extracellular vesicles and synthetic nanoparticles, although no new clinical results are reported.

This review explores current strategies to enhance extracellular vesicle-based delivery of CRISPR/Cas systems, addressing efficiency challenges and suggesting future directions to bridge gene editing technologies with clinical applications.

This review discusses the potential of extracellular vesicles as cell-free tools in tissue engineering and regenerative medicine, noting their emerging role in promoting tissue repair without the risk of host rejection.

This review discusses the role of extracellular vesicles in dermatology for therapeutic, diagnostic, and prognostic purposes, highlighting the lack of validated findings and the necessity for more rigorous clinical trials.

This review explores the potential of extracellular vesicle therapy as a novel strategy to delay intervertebral disc degeneration and enhance tissue repair, by modulating key pathogenic mechanisms, with a focus on the molecular components and bioengineering modifications of extracellular vesicles.

This study found that extracellular vesicles from mesenchymal and outer root sheath stem cells may inhibit hair follicle stem cell apoptosis, suggesting potential therapeutic benefits for hair loss treatments.

This study demonstrated that a novel hydrogel combining extracellular vesicles from chemically induced mammary epithelial cells with chitosan significantly enhanced skin wound healing in a rat model.

This study found that extracellular vesicles derived from cardiosphere-derived cells classified as potent were effective in reducing cardiac hypertrophy and improving systemic health markers in rats with induced cardiac aging.

This study reports that extracellular microvesicles isolated from stimulated dermal fibroblasts enhanced hair follicle growth ex vivo and identified norrin as a novel modulator in hair regeneration processes.

This paper reviews the emerging potential of menstrual blood-derived mesenchymal stem cell extracellular vesicles in regenerative medicine, highlighting their promise for treating several diseases without providing new clinical results.

This review analyzed 12 clinical studies on extracellular vesicle therapies, finding potential benefits for skin aging, acne scars, alopecia, and wound healing, but highlighted significant challenges like production standardization and lack of large-scale studies.

This review discusses the potential of stem cell-derived extracellular vesicles for improving diabetic wound healing and highlights their mechanisms, limitations, and challenges, but provides no new clinical findings.

This study found that low androgen levels in rat penile endothelial cells were associated with a decrease in eNOS-expressing extracellular vesicles and reduced nitric oxide production.

This review discusses current research and interest in extracellular vesicles for applications in plastic surgery and underscores the need for standardized protocols and further evidence to inform clinical use.

This study observed that plant-derived extracellular vesicles delivered through a microneedling technique showed favorable tolerance and subjective improvement in androgenetic alopecia patients, with 95% reporting perceived improvement and 85% experiencing no adverse effects after six sessions.

This systematic review found that exosome-based therapies significantly improve skin elasticity, reduce wrinkle depth, enhance hydration, and modulate pigmentation, with minimal adverse events reported across multiple studies. However, further clinical trials are necessary to confirm long-term efficacy and safety.

This review highlights the potential of extracellular vesicles derived from medicinal plants as therapeutics for diseases such as cancer and inflammation, suggesting they may enhance the clinical use of herbal preparations, despite the challenges posed by extract complexity and individual variability.

This review discusses the isolation, characterization, and potential clinical applications of tissue-derived extracellular vesicles in cancer diagnosis, prognosis, and treatment, noting their significance but highlighting the risks and need for appropriate protocols.

This preclinical study found that exercise-induced extracellular vesicles delayed breast cancer tumor growth in mice, potentially by enhancing the immune response within the tumor microenvironment.

This review discusses the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles and modern technologies like 3D bioprinting but reports no new clinical results.

In this review, researchers discussed the potential of mesenchymal stem cells and their exosomes as a promising therapy for burn injuries, emphasizing their role in inflammation regulation, tissue regeneration, and overcoming challenges in clinical translation, but noting obstacles in standardization and quality control.

In this study, iPSC-derived epidermal organoids demonstrated potential as a novel tool for regenerative medicine by producing high-performance extracellular vesicles that promote proliferation, migration, and angiogenesis in cell-free therapies for wound healing.

In this study, extracellular vesicles derived from amniotic fluid stem cells enhanced fetal lung development in models of pulmonary hypoplasia, showing promise for therapeutic application.

This review found that vesicle-based therapies, including mammalian MSC-derived and plant-derived vesicles, consistently promote wound healing in preclinical models of thermal injury and may offer a safer alternative to live cell transplants.

This review suggests that extracellular vesicles and conditioned media might be safe and effective for skin rejuvenation and lightening, but further high-quality studies are needed to confirm these findings.

In this study, researchers developed a new SFL-3D system to produce extracellular vesicles from rejuvenated dermal papilla cell spheroids, which demonstrated significant antifibrotic effects in reducing hypertrophic scarring, highlighting their potential for precision-targeted scar management.

In a study using an AGA mouse model, researchers observed that a novel topical gel combining hybrid extracellular vesicles, gold nanoparticles, and finasteride accelerated hair regrowth and improved hair quality more effectively than conventional minoxidil treatment, presenting a promising option with fewer side effects.