The Effect of Oxygen Supply Using Perfluorocarbon-Based Nanoemulsions on Human Hair Growth

January 2024 in “ Journal of materials chemistry. B ”

Phil June Park, Himangsu Mondal, Bong Soo Pi, Sung Tae Kim, Jun‐Pil Jee

perfluorocarbon-based nanoemulsion PFOB-NE oxygen supply hair dermal papilla cells hDPCs hair growth lactate accumulation lactate dehydrogenase activity oxygen deficiency human hair organ elongation perfluorocarbon nanoemulsion oxygenating nanoemulsion hair papilla cells lactate LDH hair elongation

TLDR A new nanoemulsion increases oxygen for hair cells, leading to better hair growth.

The study presents a perfluorocarbon-based nanoemulsion (PFOB-NE) designed to enhance oxygen supply to hair dermal papilla cells (hDPCs), which are crucial for hair growth. The PFOB-NE was able to release oxygen continuously for 36 hours, increasing the oxygen concentration in anoxic microenvironments from less than 0.2% to 0.8%. This improved oxygen supply led to the promotion of hDPC growth, reduction of lactate accumulation, increased lactate dehydrogenase activity, and upregulation of genes related to oxygen deficiency. As a result, human hair organ elongation was approximately four times greater with the PFOB-NE treatment compared to the control in anoxic conditions, suggesting that this oxygenating nanoemulsion could be a significant method for promoting hair growth and preventing hair loss.

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