In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells

October 2021 in “ BioMed Research International ”

Nicola Zerbinati, Sabrina Sommatis, Cristina Maccario, Maria Chiara Capillo, S. Di Francesco, Raffaele Rauso, Marina Protasoni, Edoardo D’Este, Daniela Dalla Gasperina, Roberto Mocchi

noncrosslinked hyaluronic acid HYDRO DELUXE BIO human follicle dermal papilla cells HFDPCs hair growth-related genes UVB-induced oxidative damage Vascular Endothelial Growth Factor VEGF HA

TLDR Noncrosslinked hyaluronic acid helps human hair cells grow and could be a potential hair loss treatment.

The research investigated the effects of noncrosslinked hyaluronic acid (HA) on hair growth, specifically using a product called HYDRO DELUXE BIO on human follicle dermal papilla cells (HFDPCs). The study found that noncrosslinked HA significantly promoted the proliferation of HFDPCs and increased the expression of hair growth-related genes. The HYDRO DELUXE BIO product was found to be non-toxic, protected against UVB-induced oxidative damage, and increased cell viability by 12% and 19% at concentrations of 40 and 80 mg/ml, respectively. It also increased the secretion of Vascular Endothelial Growth Factor (VEGF), a key mediator in hair growth, by 9% and 12% at the same concentrations. These findings suggest that noncrosslinked HA and the HYDRO DELUXE BIO product could potentially be used as effective treatments for hair loss, but further in vivo experiments are needed to confirm these results.

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