In Vitro Evaluation of the Effect of a Non-Cross-Linked Hyaluronic Acid Hydrogel on Human Keratinocytes for Mesotherapy

February 2021 in “ Gels ”

Nicola Zerbinati, Sabrina Sommatis, Cristina Maccario, Maria Chiara Capillo, S. Di Francesco, Raffaele Rauso, Marina Protasoni, Edoardo D’Este, Daniela Dalla Gasperina, Roberto Mocchi

hyaluronic acid HYDRO DELUXE BIO human keratinocytes mesotherapy scalp interleukin-8 Tumor Necrosis Factor Vascular Endothelial Growth Factor angiogenesis hair growth oxidative stress cell survival biorevitalization hair follicle HA Hydro Deluxe Bio IL-8 TNF VEGF

TLDR HYDRO DELUXE BIO hyaluronic acid hydrogel is compatible with skin cells, may reduce inflammation, promote blood vessel growth, and protect against oxidative stress, suggesting it could help revitalize hair follicles.

The study evaluated the effects of HYDRO DELUXE BIO, a non-cross-linked hyaluronic acid hydrogel, on human keratinocytes in vitro. The hydrogel showed high biocompatibility, reduced inflammation by lowering IL-8 levels, increased VEGF expression indicating enhanced angiogenesis, and protected against oxidative stress, improving cell survival. These findings suggested that HYDRO DELUXE BIO could be a promising candidate for mesotherapy treatments aimed at hair follicle biorevitalization and scalp health.

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