March 2025 in “Research Square (Research Square)” This study explored the potential of the lysate and lipoteichoic acid from Lactiplantibacillus plantarum APsulloc 331261 to improve scalp seborrheic dermatitis by modulating inflammatory and lipogenesis pathways in vitro, suggesting potential as a natural treatment option.
21 citations
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April 1995 in “Mayo Clinic Proceedings” This case study describes a testosterone-secreting adrenal adenoma in a 55-year-old woman, highlighting the presence of Reinke's crystalloids, suggesting that Leydig cells may play a role in such tumors.
March 2023 in “Clinical Cosmetic and Investigational Dermatology” This commentary reviews methods for delivering adipose-derived mesenchymal stem cell secretome for facial skin rejuvenation and does not report new clinical results; the authors discuss addressing concerns about administration methods and product characterization.
79 citations
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December 1990 in “Clinical endocrinology” This review explores the mechanisms of intratesticular control of steroidogenesis and indicates the need for further controlled studies; it presents no new experimental findings.
This study suggests that 5alpha-dihydroprogesterone could be an effective, non-sedative anticonvulsant for drug-resistant complex partial seizures, as observed in a rat model.
1 citations
,
June 2024 in “Skin Research and Technology” This study found that secretory proteins in DFCM play crucial roles in regulating nerve restoration by forming significant protein interaction networks during the wound repair process.
8 citations
,
January 2021 in “Pharmaceutics” This study found that using nanoporous silica entrapped lipid-drug complexes enhanced the solubility and bioavailability of dutasteride in beagle dogs.
February 2026 in “International Journal of Molecular Sciences” In this study, Lrig1-positive stem cells in mouse hair follicles were found to be essential for sebaceous gland formation and maintenance, with their depletion causing a temporary loss of these glands and changes in cellular differentiation.
April 2023 in “Journal of Investigative Dermatology” This study found that MPZL3 plays a crucial role in controlling sebaceous gland size and sebocyte proliferation in mice and humans, implicating its potential involvement in skin disorders like acne and psoriasis.
December 2006 in “Experimental Dermatology” This review discusses the role of adipose tissue as an endocrine organ affecting skin physiology and suggests a complex interaction between adipocytes and the skin as part of the broader endocrine system, but provides no new clinical results.
35 citations
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September 2009 in “Development” This study found that overexpression of the intercellular adhesion protein Necl2 in hair follicle stem cells was associated with reduced cell proliferation and delayed wound healing in both cultured cells and transgenic mice.
110 citations
,
April 2009 in “Cell Motility and the Cytoskeleton” This review discusses the intracellular activity of β-thymosins and their role in modulating the actin cytoskeleton, but it reports no new experimental results.
9 citations
,
January 2013 in “BioMed research international” This article suggests targeting the water activity within pilosebaceous follicles using biocompatible solutes like xylose and sucrose as a new potential topical treatment for acne.
33 citations
,
May 2018 in “Stem Cell Reports” This study demonstrates that Krt15 marks long-lived, multipotent, and injury-resistant crypt cells in the small intestine, which may serve as the cell of origin in intestinal cancer.
January 1990 in “Insula-revista De Letras Y Ciencias Humanas” This review discusses the skin's role as a peripheral endocrine organ, highlighting its complex hormonal interactions and the endocrine functions it performs, but reports no new findings.
44 citations
,
February 2009 in “Pain” This study found that progesterone can inhibit spinal reflex potentiation in ovariectomized rats through GABA(A) receptor activity, mediated by neurosteroid metabolism rather than direct progesterone receptor action.
3 citations
,
July 2017 in “Journal of Investigative Dermatology” This study found that SSEA-4 is a marker that distinguishes eccrine from apocrine ductal cells in human sweat glands, suggesting its potential use in diagnostic applications.
20 citations
,
January 2023 in “Frontiers in Immunology” This review discusses the role of skin-associated adipocytes in modulating skin immune responses and infection, reporting no new experimental results.
1 citations
,
October 2018 in “Bioscience reports” This study suggests that Annexin A2 isoform 2 might play a role in regulating the proliferation and growth of dermal papilla cells, potentially impacting the hair follicle growth cycle.
This study found that testosterone enhances glucose-stimulated insulin secretion in male and female human islets, requiring conversion to DHT and E2 via SRD5A1 and aromatase.
1 citations
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May 2025 in “Natural Products and Bioprospecting” In this study, PEVIII, a nanocomposite chitosan-coated vesicle containing both α-hederin and hederacoside C, demonstrated notable antibacterial activity against Pseudomonas aeruginosa in a keratitis model, showing significant lesion reduction, tissue improvement, and decreased bacterial load and inflammatory markers compared to other treatments.
September 2024 in “Journal of Cosmetic Dermatology” In this study, researchers found that Ectoin, derived from halophilic bacteria, can mitigate stress-related skin damage by reducing cortisone's inhibitory effects on essential skin proteins and decreasing UVB-induced glucocorticoid activity, highlighting its potential as a preventative agent for stress-induced skin issues.
September 2017 in “Journal of Investigative Dermatology” This study suggests that the newly characterized sebocytic progenitor cells HSGC1 and HSGC2 from different skin sites may have proliferative and differentiating potential in response to DHT.
April 2016 in “International Journal of Drug Delivery” This study found that finasteride ethosome formulations with specific ethanol and soya lecithin concentrations significantly enhanced transdermal drug delivery compared to a potential nanogel.
39 citations
,
April 2019 in “The journal of immunology/The Journal of immunology” This study found that Malt1, particularly its protease activity, plays a crucial role in maintaining Treg cell function and homeostasis, with its inactivation leading to autoimmune diseases and altered immune responses in mice.
48 citations
,
January 2003 In this study, researchers isolated and identified diverse endophytes from plants in Asia, finding that these microorganisms have significant potential for producing useful metabolites, including enzymes and antibiotics.
37 citations
,
December 1995 in “Journal of Cell Science” This study found that nexin 1 mRNA, a potent protease inhibitor, is prevalent in rat follicular papilla cells and may play a role in regulating hair follicular growth.
17 citations
,
May 2021 in “Journal of Applied Pharmaceutical Science” This review highlights that transferosomes, or ultradeformable lipids, show promise for improving dermal delivery, exhibiting efficient drug transport across the skin's barrier and offering potential benefits for treating chronic skin disorders with better bioavailability.
6 citations
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April 2004 in “Journal of Enzyme Inhibition and Medicinal Chemistry” This study found that four new progesterone derivatives reduced prostate weight in gonadectomized hamsters, suggesting potent in vivo antiandrogenic effects similar to finasteride.
October 2010 in “Epilepsy Currents” This study found that inhibitory neurosteroids synthesized within glial cells can reduce seizure frequency in epileptic animals by enhancing inhibitory transmission via γ-aminobutyric acid receptors.