A Comparative Study on Adipose-Derived Mesenchymal Stem Cells Secretome Delivery Using Microneedling and Fractional CO2 Laser for Facial Skin Rejuvenation

March 2023 in “ Clinical Cosmetic and Investigational Dermatology ”

Shannaz Nadia Yusharyahya, Valdi Ven Japranata, Irma Bernadette S. Sitohang, Lili Legiawati, Endi Novianto, Lis Surachmiati Suseno, Karin Rachmani

adipose-derived mesenchymal stem cells secretome microneedling fractional CO2 laser facial skin rejuvenation anti-aging wound repair

TLDR Microneedling and fractional CO2 laser are compared as methods for delivering stem cell secretomes for skin rejuvenation.

The authors of the study on adipose-derived mesenchymal stem cells (ADMSCs) secretome delivery for facial skin rejuvenation respond to feedback by clarifying that their research focuses on comparing microneedling and fractional CO2 laser as delivery methods, rather than exploring the efficacy of the secretome itself. They acknowledge the importance of secretome dosage and characterization but note that specific protein concentrations cannot be disclosed due to proprietary reasons. The study highlights the potential of stem cell secretomes in dermatology, including anti-aging and wound repair benefits, while emphasizing the need for further research on delivery methods.

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research Mesenchymal Stem Cell Secretome for Dermatology Application: A Review

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