Specific In Vivo Ablation of Lrig1-Positive Follicular Progenitor Cells Results in Sebaceous Gland Loss in Mice

February 2026 in “ International Journal of Molecular Sciences ”

Laurent Barnes, Fabienne Fontao, Evangelia Konstantinou, J. Saurat, Olivier Sorg, G Kaya

Lrig1-positive follicular progenitor cells sebaceous glands junctional-zone keratinocytes interfollicular epidermis sebocytes hair cycling EGFR Wnt/β-catenin Lrig1 cells SGs epidermis hair growth epidermal growth factor receptor Wnt signaling

Studysummary In this study, Lrig1-positive stem cells in mouse hair follicles were found to be essential for sebaceous gland formation and maintenance, with their depletion causing a temporary loss of these glands and changes in cellular differentiation.

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