Stage-Specific Embryonic Antigen-4 (SSEA-4) as a Distinguishing Marker Between Eccrine and Apocrine Origin of Ducts of Sweat Glands

    July 2017 in “ Journal of Investigative Dermatology ”
    Julia Borowczyk, Eliza Zimoląg, Piotr Konieczny, Anna Chrapusta, Zbigniew Madeja, Justyna Drukała
    TLDR SSEA-4 can distinguish between eccrine and apocrine sweat gland ducts.
    The study investigated the presence of Stage-Specific Embryonic Antigen-4 (SSEA-4) as a marker to distinguish between eccrine and apocrine sweat gland ducts. Skin biopsy samples from 9 healthy patients revealed that SSEA-4 was present in all cells of eccrine ducts but absent in apocrine ducts. This finding suggested that SSEA-4 could serve as a reliable marker for differentiating between these two types of sweat gland ducts, which was significant for developing diagnostic markers for sweat gland tumors. Other markers like carcinoembryonic antigen (CEA), keratin 16 (K16), and keratin 17 (K17) were not effective for this distinction. The study concluded that SSEA-4 might be the first antigen to enable histological differentiation between eccrine and apocrine ducts, potentially aiding in future diagnostic applications.
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