January 2024 in “Reproductive toxicology” This study found that hesperidin, a bioflavonoid, mitigated the negative effects of finasteride on sperm health and testicular structure in male Wistar rats by reducing oxidative stress and apoptosis and supporting testicular antioxidant capacity.
210 citations
,
May 2006 in “The FASEB journal” This study found that oxidative stress in hair follicle melanocytes contributes to premature aging and apoptosis, providing insights into graying as a model for studying aging and testing antiaging therapies.
May 2015 in “Cancer Research” This study found that a new treatment candidate may effectively prevent and promote recovery from chemotherapy-induced alopecia by normalizing apoptosis and reducing inflammation in cancer patients.
72 citations
,
January 2012 in “Annals of Dermatology” In this study, IGF-I was shown to enhance human hair follicle growth, maintain the anagen phase, and increase expression of certain growth factors and anti-apoptotic markers.
43 citations
,
December 2006 in “The American journal of pathology” This study found that Edar signaling plays a role in regulating the hair cycle and apoptosis in hair follicle keratinocytes during the catagen phase in mice.
15 citations
,
June 2015 in “Human Cell” This study found that forming spheroids using silicone micro-wells improved the viability and neural differentiation potential of human adipose-derived stem cells after thawing.
September 2023 in “International journal of molecular sciences” In this study involving ICR mice, researchers found that Korean red pine bark extract improved cognitive functions impaired by TMT through mechanisms like antioxidant system protection, cholinergic and synaptic support, mitochondrial regulation, and reduction of neuro-inflammation and apoptosis.
30 citations
,
April 2017 in “European Journal of Cell Biology” This study observed that CIP/KIP proteins play a significant role in regulating cell cycle arrest and differentiation in human hair follicles, supporting hair growth and formation in the anagen phase.
This study found that quercetin significantly promoted proliferation and inhibited apoptosis of hair follicle stem cells from Arbas cashmere goats, suggesting potential benefits for improving cashmere production.
2 citations
,
July 2025 in “Cells” This study reports that human adipose-derived stem cells cultured with platelet lysate instead of fetal bovine serum demonstrate enhanced stress resistance, reduced cellular aging, and faster wound healing in mice, due in part to upregulated stress response and proliferation genes.
4 citations
,
January 2024 in “Allergy” This study indicates that individuals exposed to PPD mount varying immune responses, with either tolerance, subclinical inflammation, or allergy, suggesting no true non-responders to PPD.
13 citations
,
July 2019 in “Journal of Biochemical and Molecular Toxicology” In this study on rat dermal papilla cells, hydroxytyrosol, an antioxidant found in olive oil, was reported to protect against oxidative stress, reduce inflammation, and enhance hair growth factors, suggesting its potential to prevent hair loss.
November 2023 in “Experimental Dermatology” In this study, researchers found that exosomes derived from dermal sheath cup cells (Exo DSCCs) improved proliferation, viability, and migration while reducing apoptosis in senescent dermal papilla cells, also enhancing hair follicle reconstruction and suggesting a potential strategy for combating senile alopecia.
6 citations
,
March 2011 in “Experimental Dermatology” This study found that an imbalance of selenium in a C57BL/6 mouse model led to hair loss with color change and was linked with changes in hair follicle apoptosis markers.
March 2025 in “International Journal of Molecular Sciences” Veratric Acid may help promote hair growth and reduce hair loss.
11 citations
,
October 2024 in “Cell Death Discovery” In this study on mice with severe thermal skin burns, researchers found that administering 4-aminopyridine (4-AP) helped reduce inflammation and apoptosis, promoted angiogenesis, and accelerated wound healing by enhancing specific cellular behaviors and signaling pathways.
42 citations
,
September 2012 in “PLoS ONE” In this study, bezafibrate treatment improved certain aging-like features in a mouse model with mitochondrial dysfunction, but did not enhance muscle function or lifespan.
9 citations
,
May 2021 in “Frontiers in aging neuroscience” This study found that long-term use of triterpenoids from Ganoderma lucidum may improve brain function and alleviate aging-related issues in normal and Alzheimer's mouse models.
18 citations
,
October 2021 in “Frontiers in Physiology” This review summarizes recent research on the molecular properties and functions of L-PGDS and PGD2, but reports no new findings, highlighting their pathophysiological roles and guiding future studies.
20 citations
,
November 2022 in “Nutrients” This review summarizes existing reports on placenta extract for treating liver injury and discusses its mechanisms but provides no new clinical results.
13 citations
,
July 2015 in “Archives of dermatological research” This study found that the spermidine analog N1-methylspermidine prolonged hair follicle growth and decreased inflammation and oxidative stress in cultured hair follicles, suggesting potential relevance for treating inflammatory scalp diseases.
25 citations
,
September 2020 in “Molecules” In this study, quercitrin was reported to promote hair growth and cell viability in cultured human dermal papilla cells by enhancing cellular energy metabolism and growth factor production via MAPK/CREB signaling.
6 citations
,
December 2010 in “Journal of Cosmetic Dermatology” This study suggests that low proliferation rates in bald areas of androgenetic alopecia patients, along with persistent inflammatory infiltrate, may lead to follicular miniaturization and fibrosis.
2 citations
,
April 2017 in “Molecular Medicine Reports” In this study, blocking autophagy with 3-methyladenine significantly improved the survival of inner ear hair cells in a gentamicin-induced ototoxic mouse model.
4 citations
,
July 2020 in “BMC Complementary Medicine and Therapies” This study suggests that human placenta treatment may promote hair regrowth in chemotherapy-induced alopecia by inhibiting apoptosis and encouraging hair follicle proliferation in a mouse model.
253 citations
,
March 1994 in “Developmental dynamics” This study suggests that programmed cell death plays a crucial role in shaping the structure of the human epidermis and its appendages during development.
15 citations
,
July 2019 in “Journal of Investigative Dermatology” This exploratory study found that cannabidiol (CBD) at higher concentrations may inhibit hair growth by promoting the onset of catagen in human hair follicles, while lower concentrations showed potential anti-inflammatory effects without promoting catagen.
6 citations
,
July 2018 in “Advances in Clinical and Experimental Medicine” This study found that scalp hair follicles had higher expression of cytokeratin 15 and distinct hair layers compared to other body regions, highlighting differences in hair follicle characteristics.
January 2022 in “Biomedical Reports” This study suggests that inaudible sound at 30 kHz may promote hair growth and inhibit hair loss signals in human dermal papilla cells, indicating potential as a new treatment for androgenic alopecia.
10 citations
,
August 2021 in “EMBO Reports” This study found that the anti-apoptotic Bcl-2 protein plays a crucial role in maintaining hair follicle stem cell function and influences tissue regeneration and tumor formation in mice.