Quercetin Promotes Production of Secondary Hair Follicle Stem Cells in Cashmere Goat: A Mechanistic Study

August 2025

Wei Lian, Guoqing Jiang, Xueyong Wu, Yuping Gao, Kun Cui, Lei Zhu, Ziyang Xu, Xiaoxin Zhang, Jiawei Wang, Mingli Peng, Rui Ding, Fei Hao, Dongjun Liu

quercetin secondary hair follicle stem cells SHFSCs proliferation markers PCNA TERT apoptosis PI3K–Akt signaling pathway Wnt signaling pathway TGF-β signaling pathway cellular energy metabolism antioxidant status

TLDR Quercetin can boost hair follicle stem cell growth in cashmere goats, potentially improving cashmere quality.

This study explores the impact of quercetin on secondary hair follicle stem cells (SHFSCs) in Arbas cashmere goats, highlighting its potential to enhance cashmere production. Quercetin, known for its antioxidant and anti-inflammatory properties, was found to promote SHFSC proliferation and inhibit apoptosis, with an optimal concentration of 10 μg/mL for 48 hours. It increased the expression of proliferation markers like PCNA and TERT, improved mitochondrial function, reduced oxidative stress, and influenced key signaling pathways such as PI3K–Akt, Wnt, and TGF-β. These findings suggest quercetin's potential to improve cashmere quality by modulating SHFSC activity, although further in vivo studies are needed for validation.

View this study on preprints.org →

Discuss this study in the Community →

Related Research

5 / 5 results

research Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats

2 citations, February 2022 in “Genomics”

Researchers discovered new cell types in goat hair follicles that could help understand hair regrowth and human hair loss.

research Shedding Light on Cashmere Goat Hair Follicle Biology: From Morphology Analyses to Transcriptomic Landscape

8 citations, July 2020 in “BMC genomics”

The research found genes that change during cashmere goat hair growth and could help determine the best time to harvest cashmere.

research Hair Follicle Transcriptome Profiles During the Transition from Anagen to Catagen in Cashmere Goat (Capra Hircus)

14 citations, January 2015 in “Genetics and molecular research”

The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.

research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

61 citations, April 2013 in “PloS one”

The study found key genes and pathways involved in cashmere goat hair growth stages.

research Hoxc13/β-Catenin Correlation with Hair Follicle Activity in Cashmere Goat

22 citations, July 2012 in “Journal of integrative agriculture/Journal of Integrative Agriculture”

Hoxc13 is linked to seasonal hair growth in Cashmere goats and is affected by melatonin.

Quercetin Promotes Production of Secondary Hair Follicle Stem Cells in Cashmere Goat: A Mechanistic Study

Related Community Posts Join

community What is the ultimate hair regrowth protocol

community 6 months progress (minox and keto only)

community Have people with aggressive balding genetics genuinely had any results after applying any natural remedies ie:rosemary oil,coconut oil,Onion Juice etc

community dunno if it's growing anything but it's making my scalp red

community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.