Quercetin Promotes Production of Secondary Hair Follicle Stem Cells in Cashmere Goat: A Mechanistic Study

August 2025

Wei Lian, Guoqing Jiang, Xueyong Wu, Yuping Gao, Kun Cui, Lei Zhu, Ziyang Xu, Xiaoxin Zhang, Jiawei Wang, Mingli Peng, Rui Ding, Fei Hao, Dongjun Liu

quercetin secondary hair follicle stem cells SHFSCs proliferation markers PCNA TERT apoptosis PI3K–Akt signaling pathway Wnt signaling pathway TGF-β signaling pathway cellular energy metabolism antioxidant status

TLDR Quercetin can boost hair follicle stem cell growth in cashmere goats, potentially improving cashmere quality.

This study explores the impact of quercetin on secondary hair follicle stem cells (SHFSCs) in Arbas cashmere goats, highlighting its potential to enhance cashmere production. Quercetin, known for its antioxidant and anti-inflammatory properties, was found to promote SHFSC proliferation and inhibit apoptosis, with an optimal concentration of 10 μg/mL for 48 hours. It increased the expression of proliferation markers like PCNA and TERT, improved mitochondrial function, reduced oxidative stress, and influenced key signaling pathways such as PI3K–Akt, Wnt, and TGF-β. These findings suggest quercetin's potential to improve cashmere quality by modulating SHFSC activity, although further in vivo studies are needed for validation.

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