Molecular Insights into the Superiority of Platelet Lysate over FBS for Human Adipose-Derived Stem Cell Expansion and Wound Healing

    July 2025 in “ Cells ”
    Sakurako Kunieda, Michika Fukui, Atsuyuki Kuro, Toshihito Mitsui, Huan Li, Zhongxin Sun, Takayuki Ueda, Shigeru Taketani, Koichiro Higasa, Natsuko Kakudo
    TLDR Platelet lysate is better than fetal bovine serum for growing stem cells and healing wounds.
    This study demonstrates that platelet lysate (PL) is superior to fetal bovine serum (FBS) for expanding human adipose-derived stem cells (hASCs) and enhancing wound healing. RNA sequencing and functional assays showed that PL upregulates genes related to cell proliferation and stress resistance, leading to improved resilience against oxidative and genotoxic stress, reduced apoptosis, and decreased cellular aging markers. In vivo experiments in mice revealed that PL-treated wounds healed faster with thicker dermis-like tissue and increased angiogenesis. These findings suggest that PL is a promising alternative to FBS, offering enhanced regenerative efficacy and safety for hASC expansion and wound healing applications.
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