Molecular Insights into the Superiority of Platelet Lysate over FBS for Human Adipose-Derived Stem Cell Expansion and Wound Healing

    July 2025 in “ Cells ”
    Sakurako Kunieda, Michika Fukui, Atsuyuki Kuro … Natsuko Kakudo
    Studysummary This study reports that human adipose-derived stem cells cultured with platelet lysate instead of fetal bovine serum demonstrate enhanced stress resistance, reduced cellular aging, and faster wound healing in mice, due in part to upregulated stress response and proliferation genes.
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    Research cited in this study 6

    1. Adipose-Derived Stem Cells in Skin Diseases, Wound Healing, and Skin Defects: A Review Cytotherapy · 2022
    2. Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation International Journal of Molecular Sciences · 2021
    3. Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia International Journal of Molecular Sciences · 2020
    4. Hopes and Limits of Adipose-Derived Stem Cells and Mesenchymal Stem Cells in Wound Healing International journal of molecular sciences · 2020
    5. Mesenchymal Stem Cells and Stromal Vascular Fraction for Hair Loss Facial Plastic Surgery Clinics of North America · 2018
    6. The Use of Stem Cells in Plastic and Reconstructive Surgery Advances in Clinical and Experimental Medicine · 2014