4-Aminopyridine Attenuates Inflammation and Apoptosis and Increases Angiogenesis to Promote Skin Regeneration Following a Burn Injury in Mice

The study investigates the use of 4-aminopyridine (4-AP), a drug approved for multiple sclerosis, to treat severe burn injuries in mice. The research found that 4-AP significantly reduces inflammation and apoptosis while promoting angiogenesis, which accelerates wound healing. Specifically, 4-AP decreased pro-inflammatory cytokines and apoptotic markers while increasing anti-inflammatory and anti-apoptotic markers. It also enhanced angiogenesis and keratinocyte proliferation, contributing to faster wound closure. In later healing stages, 4-AP increased markers associated with fibroblast transformation and collagen production. These findings suggest that 4-AP could be a promising therapeutic agent for improving burn wound healing.