4-Aminopyridine Attenuates Inflammation and Apoptosis and Increases Angiogenesis to Promote Skin Regeneration Following a Burn Injury in Mice

    October 2024 in “ Cell Death Discovery ”
    V G Rahul, Govindaraj Ellur, Amir A. Gaber … John C. Elfar
    Studysummary In this study on mice with severe thermal skin burns, researchers found that administering 4-aminopyridine (4-AP) helped reduce inflammation and apoptosis, promoted angiogenesis, and accelerated wound healing by enhancing specific cellular behaviors and signaling pathways.
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    Research cited in this study 10

    1. Cell Death as an Architect of Adult Skin Stem Cell Niches Cell death and differentiation · 2024
    2. Cooperation of TGF-β and FGF Signalling Pathways in Skin Development Cell Proliferation · 2023
    3. Macrophages in Skin Wounds: Functions and Therapeutic Potential Biomolecules · 2022
    4. Store-Operated Calcium Channels in Skin Frontiers in Physiology · 2022
    5. Gene Therapy to Enhance Angiogenesis in Chronic Wounds Molecular Therapy — Nucleic Acids · 2022
    6. Cell Death in Skin Function, Inflammation, and Disease Biochemical Journal · 2022
    7. 4-Aminopyridine Induces Nerve Growth Factor to Improve Skin Wound Healing and Tissue Regeneration Biomedicines · 2022
    8. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth Cell Stem Cell · 2019
    9. Secreted Frizzled-Related Protein 4 Inhibits the Regeneration of Hair Follicles PeerJ · 2019
    10. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014