4-Aminopyridine Promotes Accelerated Skin Wound Healing via Neurogenic-Mediator Expression

    March 2022 in “ Research Square (Research Square) ”
    Mashanipalya Jagadeeshaprasad, Prem Kumar Govindappa, Amanda M. Nelson, Mark David Noble, John C. Elfar
    Image of study
    TLDR 4-aminopyridine, a FDA-approved drug, speeds up skin wound healing and tissue regeneration.
    The document reveals that 4-aminopyridine (4-AP), a potassium channel blocker approved by the FDA, significantly improves skin wound healing. This includes faster wound closure, restoration of normal skin structure, increased vascularization and reinnervation, and enhanced hair follicle neogenesis. The study found that 4-AP increased levels of vimentin and alpha-smooth muscle actin in the healed dermis, contributing to tissue regeneration. It also promoted neuronal regeneration, as evidenced by increased numbers of axons and S100+ Schwann cells, and elevated expression of SRY-Box Transcription Factor 10. The treatment also boosted levels of transforming growth factor-β, substance P, and nerve growth factor, all crucial for wound healing. In-vitro studies showed that 4-AP enhanced the proliferation and migration of human keratinocytes and Schwann cells, and improved cellular interactions to accelerate wound healing. Therefore, 4-AP enhances many key aspects of successful wound healing and presents a promising new approach to improve skin wound healing and tissue regeneration.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community 4 months progress taking po fin+min

      in Progress Pictures  47 upvotes 6 days ago
      The user reported hair recovery on the scalp after 4 months using finasteride and 5% topical minoxidil, with anxiety as a side effect. Reducing caffeine intake helped manage anxiety, which may be linked to minoxidil's effects.

      community 4 months progress using 2.5mg min, 1mg fin and 10mg biotin.

      in Progress Pictures  38 upvotes 1 week ago
      A user shared their 4-month progress using 2.5mg minoxidil, 1mg finasteride, and 10mg biotin, noting slight testicular discomfort initially but no significant hairline changes yet. Another user reported similar treatment results, with hair darkening at the scalp center and small temple hairs.

      community 4 months on Dut, Min and Nizoral

      in Progress Pictures  108 upvotes 2 weeks ago
      The user reported significant hair regrowth after 4 months using Dutasteride, oral and topical Minoxidil, Nizoral shampoo, and dermastamping. They experienced minor side effects but noted consistent progress and regrowth, especially at the hairline and temples.

      community 4 months on 2.5mg Dut + 5mg oral minox daily

      in Progress Pictures  117 upvotes 2 weeks ago
      The conversation is about a user's positive experience with hair regrowth using 2.5mg daily of Dutasteride and 5mg oral Minoxidil, noting significant progress without major side effects. The user experienced an initial hair shed with Dutasteride, which stopped after starting Minoxidil, and recommends consulting a doctor before adjusting dosages.

    Related Research

    1 / 1 results