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    Glossary Androgen Signaling

    process where male hormones bind to cell receptors

    Androgen signaling refers to the process by which androgens, which are male hormones like testosterone, bind to specific receptors in cells to regulate various biological functions. This signaling pathway is crucial for the development and maintenance of male characteristics, but it also plays a role in conditions like androgenetic alopecia (pattern hair loss) by affecting hair follicle health and growth.

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    1. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell · 2020 · 139 citations
    2. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    3. Regulation of masculinization: androgen signalling for external genitalia development Nature Reviews Urology · 2018 · 45 citations
    4. Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain Frontiers in Endocrinology · 2024 · 3 citations
    5. Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 2 citations
    6. Diet‐Induced Obesity Promotes Alopecia Through Oxidative Stress and Androgen Signalling in Female Mice Experimental Dermatology · 2026
    7. Androgen Signaling in Sertoli Cells theses.fr (ABES) · 2014
    8. Therapeutic Potentiality of Celtis choseniana Nakai on Androgenic Alopecia through Repression of Androgen Action and Modulation of Wnt/β-catenin Signaling Natural product sciences · 2023
    9. Androgen Receptor–Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia Journal of Investigative Dermatology · 2022 · 6 citations
    10. Androgen receptor signaling as a new target for intervention in acute myeloid leukemia Blood Advances · 2025
    11. Keratinocyte Growth Inhibition through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells 2009 · 70 citations
    12. The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells Journal of Investigative Dermatology · 2015 · 46 citations
    13. Androgen modulation of Wnt/β-catenin signaling in androgenetic alopecia Archives of Dermatological Research · 2018 · 39 citations
    14. 592 Cross-interactions of BMP and WNT signaling pathways attenuate androgen effect on HFSC differentiation Journal of Investigative Dermatology · 2019
    15. Hair Thickness Growth Effect of Adenosine Complex in Male-/Female-Patterned Hair Loss via Inhibition of Androgen Receptor Signaling International journal of molecular sciences · 2024
    16. Estrogen and androgen signaling in the pathogenesis of BPH Nature reviews. Urology · 2011 · 149 citations
    17. Stauntonia hexaphylla Extract Ameliorates Androgenic Alopecia by Inhibiting Androgen Signaling in Testosterone-induced Alopecia Mice Iranian Journal of Pharmaceutical Research · 2023
    18. Androgens Regulate Tau Phosphorylation Through Phosphatidylinositol 3-Kinase–Protein Kinase B–Glycogen Synthase Kinase 3β Signaling Neuroscience · 2022 · 14 citations
    19. Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling PloS one · 2014 · 56 citations
    20. Exosome‐derived long non‐coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β‐catenin signalling Clinical and Translational Medicine · 2025
    21. Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla Journal of Dermatological Science · 2010 · 122 citations
    22. Androgens and androgen receptor action in skin and hair follicles Molecular and Cellular Endocrinology · 2017 · 100 citations
    23. Visualising Androgen Receptor Activity in Male and Female Mice PloS one · 2013 · 89 citations
    24. Role of FGFR2-signaling in the pathogenesis of acne Dermato-endocrinology · 2009 · 63 citations
    25. Androgen Action in the Ovary Frontiers in Endocrinology · 2018 · 62 citations
    26. Specific morphogenetic events in mouse external genitalia sex differentiation are responsive/dependent upon androgens and/or estrogens Differentiation · 2012 · 51 citations
    27. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013 · 30 citations
    28. COVID-19 Severity and Androgen Receptor Polymorphism Biology · 2022 · 7 citations
    29. Selective androgen receptor modulators: a critical appraisal Frontiers in Endocrinology · 2025 · 2 citations
    30. Transcriptome analysis to identify the downstream genes of androgen receptor in dermal papilla cells BMC Genomic Data · 2022 · 1 citations