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Glossary Androgen Secretion

process of releasing male hormones into the bloodstream

Androgen secretion refers to the process by which androgens, a group of hormones that play a key role in male traits and reproductive activity, are produced and released into the bloodstream. These hormones, including testosterone, are primarily secreted by the testes in males and the adrenal glands in both males and females. Androgen secretion influences various bodily functions, such as hair growth, muscle mass, and the development of secondary sexual characteristics.

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Research

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research Effects of finasteride, a 5 alpha-reductase inhibitor, on circulating androgens and gonadotropin secretion in hirsute women.

22 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that three months of oral finasteride treatment significantly decreased dihydrotestosterone levels and hair growth in hirsute women without negatively affecting gonadotropin secretion.

research Androgen- and Estrogen-Secreting Adrenal Cancers

14 citations , December 2010 in “Seminars in Oncology”

This review discusses the diagnostic challenges of androgen and estrogen-secreting adrenal tumors and highlights that the presence of metastases is the most reliable indicator of malignancy; it reports no new clinical findings.

research Low leptin level in an obese hyperandrogenic woman – potential marker for androgen-secreting tumor

4 citations , January 2007 in “Gynecological endocrinology”

This case study suggests that low leptin levels in obese hyperandrogenic postmenopausal women might indicate the presence of androgen-secreting tumors.

Postmenopausal Virilization Due to a Rare Left Ovarian Androgen-Secreting Leydig Cell Tumor Identified by Ovarian Vein Sampling

research ODP423 Postmenopausal Virilization Secondary to A Rare Left Ovarian Androgen-Secreting Leydig Cell Tumor Localized Using Ovarian Vein Sampling

November 2022 in “Journal of the Endocrine Society”

This case report highlights the diagnostic challenge of identifying androgen-secreting ovarian Leydig cell tumors in postmenopausal women when imaging fails to reveal masses, emphasizing the usefulness of ovarian vein sampling for localization.

Case Report: Postmenopausal Hyperandrogenism Misled by Adrenal Incidentaloma: A Rare Case of Androgen-Secreting Ovarian Adult Granulosa Cell Tumor and Clinical Implications

research Case Report: Postmenopausal hyperandrogenism misled by adrenal incidentaloma: a rare case of androgen-secreting ovarian adult granulosa cell tumor and clinical implications

January 2026 in “Frontiers in Oncology”

This case report highlights that in postmenopausal women with severe hyperandrogenism, thorough adrenal and pelvic evaluations, hormonal profiling, and permanent pathology are essential for accurate diagnosis and management of androgen-secreting tumors, such as AGCTs, to prevent misdiagnosis and ensure effective treatment.

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Community Join

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community anti-androgens help with chronic seborric dermatitis ?! and hence diffuse thinning

7 upvotes 1 year ago

An 18-year-old experiencing hair loss and seborrheic dermatitis has tried finasteride, dutasteride, and various shampoos without success. They are considering anti-androgens like RU58841 and KX-826 for oil control and dandruff reduction.

community Has anyone powered through the creatine shedding (via increased androgen receptor sensitivity) and stabilized?

9 upvotes 1 year ago

Creatine may cause increased hair shedding due to androgen receptor sensitivity, despite limited evidence. The user is using dutasteride and minoxidil and seeks advice on whether shedding will stabilize, with suggestions including GHK-Cu and RU58841.

community The 'DHT itch' is real - notes from a casual bodybuilder

in Chat 115 upvotes 2 years ago

The "DHT itch" is real and likely due to inflammation at the hair follicle, exacerbated by increased testosterone or androgens. Treatments mentioned include dutasteride, minoxidil, finasteride, and various topical solutions.

community Clascoterone study going on right now

351 upvotes 2 years ago

A user is participating in a phase 3 trial for Clascoterone, a topical acne medication that may stimulate hair growth, and will share results after 6 months. They will have a section of their hair shaved and marked with a tattoo for the study.

community Serious question, is there nothing that can be done if Dutasteride doesn’t help to stop my hair loss?

60 upvotes 4 years ago

A 25 year old male who has been using finasteride and dutasteride for two years to treat his hair loss, with no success. Other treatments such as oral minoxidil, topical anti-androgens, RU58841, latanoprost, topical estrogen, CB 03 01, microneedling, keto 2% shampoo, vitamin D, Omega 3, B vitamins and probiotics were discussed.

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