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Using anabolic androgenic steroids can cause serious, lasting health problems in many parts of the body.

Testosterone treatment can improve sexual function and bone density in women but may have adverse effects and requires more research on safety and guidelines.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

Acne severity in women with PCOS is linked to younger age, lower body weight, and more body hair, but not to hormone levels.

Testosterone therapy helps boys with hormone deficiencies develop normal male characteristics and grow properly.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

Finasteride effectively treats BPH but may increase sexual dysfunction risk.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

The study found that certain microRNAs are higher in the cells and lower in the fluid of women with a specific type of polycystic ovary syndrome, and one microRNA could potentially help diagnose the condition.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.

The antiandrogen 11α-hydroxyprogesterone effectively reduces skin oil and cholesterol when applied to the skin.

Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.

Women with female pattern hair loss have lower Vitamin D3 levels.

The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).

Men with low or no sperm count have lower salivary testosterone levels, and saliva testing can measure their testosterone well.

Androgen therapy might help some women with low libido, but it has risks and should be used carefully.

Chromosomal differences affect how muscle cells respond to testosterone.

Low zinc levels in chronic liver disease patients are linked to more severe symptoms like taste issues and skin problems, and zinc supplements might help.

The document concludes that early diagnosis and treatment of PCOS in teenagers is important for managing symptoms and preventing long-term health problems.

Finasteride in male rats causes liver and metabolic issues in their offspring.

Men with early hair loss may have higher insulin resistance and should be checked for related health issues.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

Most hirsutism cases are due to PCOS, and treatment focuses on lowering testosterone and blocking its effects.

Women losing hair might have lower levels of vitamin D.

Women with PCOS are at high risk of glucose metabolism issues and heart diseases, especially if overweight, highlighting the need for early intervention.

Platelet factor 4 slows down hair growth and could make hair loss treatments more effective if removed.