Changes in Metabolic Profile in Women with a History of PCOS: A Long-Term Follow-Up Study
October 2020
in “
Journal of Clinical Medicine
”
Studysummary In this study, researchers found that overweight and obese women with polycystic ovary syndrome showed adverse changes in glucose metabolism over time, highlighting the importance of early intervention to prevent cardiometabolic diseases.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study "Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up Study" followed 31 Caucasian women with polycystic ovary syndrome (PCOS) for a median period of 120.9 months. The study found an increase in glucose concentrations, a decrease in insulin concentrations, and no changes in insulin resistance markers. No one developed diabetes, but the annualized incidence rate for conversion from normoglycemia to prediabetes was 4.5%. Prediabetes predictors in young PCOS women were identified as baseline body mass index (BMI), free androgen index, fasting glucose, and M-clamp value. Prediabetes appeared in 76.47% of the women with a final BMI of ≥ 25 kg/m² and in 7.14% of the normal-weight women. The study concluded that there is a high rate of adverse change in glucose metabolism in overweight and obese participants, a deterioration in ß-cell function, and strong correlations between metabolic parameters assessed in the third and the fourth decade in PCOS women. This emphasizes the role of early intervention to prevent cardiometabolic diseases.
