441 citations
,
May 2008 in “British Journal of Pharmacology” This article reviews the potential clinical use of anabolic steroids in treating muscle loss from chronic diseases and aging and highlights both the benefits and risks of these substances in sports.
9 citations
,
March 2019 in “European Journal of Sport Science” This article discusses laboratory and physical markers that may help detect androgenic anabolic steroid abuse in athletes and reports no new primary research results.
2 citations
,
June 2022 in “대한스포츠의학회지” This article reviews the development of selective androgen receptor modulators and myostatin inhibitors as performance-enhancing drugs, highlighting ongoing challenges in achieving truly tissue-selective anabolic agents and reporting no new experimental findings.
1 citations
,
September 2023 in “Journal of Education Health and Sport” This study provides a comprehensive analysis of anabolic-androgenic steroids, reporting that their use enhances muscle mass but is associated with significant health issues including cardiac muscle hypertrophy, liver disease, and changes in gender characteristics, emphasizing the need for patient awareness of these risks.
1 citations
,
January 2015 in “Hair therapy & transplantation” This investigation found that certain supplements, particularly whey protein isolate, growth hormones, and anabolic steroids, can negatively impact hair loss by affecting biochemical pathways.
August 2023 in “Medicina-lithuania” This review discusses the degenerative effects of anabolic-androgenic steroids on the nervous system and reports no new experimental results, aiming to increase public awareness of their health risks.
65 citations
,
April 2018 in “Oncotarget” This review discusses the potential carcinogenic effects of anabolic androgenic steroids, particularly regarding Leydig cell tumors, and highlights the need for preventive information campaigns due to associated health risks.
42 citations
,
May 2007 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism” In this animal study, administering testosterone alongside a 5α-reductase inhibitor counteracted testosterone's effects on prostate enlargement while preserving its beneficial effects on muscle and bone.
38 citations
,
September 2019 in “Chinese Medical Journal” This review discusses the cardiovascular risks associated with anabolic-androgenic steroid use and reports that, despite known toxic effects, further research is needed to clarify the causality of these risks.
36 citations
,
October 2009 in “Journal of biological chemistry/The Journal of biological chemistry” This study reports that TFM-4AS-1, a selective androgen receptor modulator, promoted bone and muscle growth with reduced effects on reproductive organs in ovariectomized rats.
34 citations
,
September 2009 in “International Journal of Dermatology” This article reviews the skin effects of anabolic-androgenic steroid use in athletes but reports no clinical results.
21 citations
,
February 2021 in “BMJ case reports” This case study potentially links the use of anabolic steroids to increased severity of COVID-19 in a healthy 28-year-old man, with marked symptom improvement following treatment with proxalutamide.
19 citations
,
June 2021 in “The world journal of men's health” This review examines the negative effects of anabolic-androgenic steroid use on the male reproductive system, including impaired testosterone production, sperm production issues, and adverse metabolic consequences without reporting new clinical results.
16 citations
,
August 1992 in “PubMed” In this study, examination of skin biopsies from individuals using anabolic-androgenic steroids revealed significant enlargement of sebaceous glands and associated increases in skin lipids and Propionibacteria acnes.
11 citations
,
November 2009 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study found that bolandiol increased lean body mass and bone mineral density in castrate adult male rats, exhibiting tissue selectivity and acting through multiple receptor pathways with less potency compared to other androgens.
8 citations
,
February 2025 in “Swiss Medical Weekly” This study observed that integrating best practices for anabolic androgenic steroid users into Swiss primary care is feasible and well-accepted, though current doping laws hinder adequate medical care for this population.
5 citations
,
January 2017 in “Biomedical Research-tokyo” This review examines the long-term health risks of anabolic-androgenic steroid abuse in athletes, reporting various physical and psychological side effects without sufficient benefits.
3 citations
,
November 2024 in “Saudi Pharmaceutical Journal” This review highlights significant health risks associated with anabolic-androgenic steroid use in women and reports no new research results, emphasizing the need for further understanding of their effects on female physiology.
3 citations
,
March 2018 in “Ars Pharmaceutica (Internet)” This review discusses the adverse effects of anabolic agents in sports, noting cardiovascular, behavioral, and other side effects, but highlights inconsistencies in the severity of cardiovascular risks.
2 citations
,
August 2025 in “Harm Reduction Journal” This study highlights the severe health risks and dependence associated with non-medical androgen use among gym-goers, stressing the need for specialized primary care and harm-reduction strategies due to potentially fatal outcomes even after prolonged cessation.
2 citations
,
July 2025 in “Forensic Sciences” This review concludes that anabolic–androgenic steroid abuse may lead to significant neurotoxicity, affecting brain structure, neurotransmitter systems, and increasing the risk of mood disorders and cognitive deficits.
2 citations
,
May 2024 in “European Journal of Investigation in Health Psychology and Education” In this study, a high prevalence of anabolic-androgenic steroid use was observed among bodybuilding athletes in Sergipe, Brazil, regardless of their socioeconomic backgrounds, highlighting the need for increased awareness about the associated health risks.
2 citations
,
January 2021 in “Cureus” This case report examines the long-term impact of extensive anabolic-androgenic steroid use on metabolic and cardiovascular health, highlighting adverse effects to guide primary care for this patient group.
2 citations
,
December 2020 in “Phytomedicine plus” In this study, researchers found that taking Saw palmetto and Pygeum africana supplements for five days altered the urinary steroid profile in a way that may interfere with the steroidal module of the Athlete Biological Passport.
2 citations
,
January 2017 in “Endocrinology” This chapter reviews the clinical effects of androgens like testosterone and its metabolites on various body systems and life stages, but reports no new results.
2 citations
,
September 1971 in “Metabolism, clinical and experimental” In this study, patients with testicular feminization syndrome showed limited anabolic responsiveness to dihydrotestosterone, potentially due to reduced affinity of nuclear receptor sites for androgenic steroids rather than defective testosterone conversion.
1 citations
,
October 2025 in “Frontiers in Cardiovascular Medicine” This review examines AAS-related deaths and finds that anabolic-androgenic steroid abuse may lead to severe cardiac abnormalities, contributing to fatal arrhythmias and sudden cardiac death in young athletes and bodybuilders.
1 citations
,
December 2024 in “Journal of Education Health and Sport” In this review, anabolic steroid use was reported to increase risks such as cardiovascular issues, liver damage, endocrine disruptions, and musculoskeletal injuries, with psychological impacts also noted, underscoring the need for education and preventive strategies.
1 citations
,
May 2024 in “The Journal of Sexual Medicine” This case report suggests that clomiphene citrate can effectively restore fertility in some men with a long history of anabolic steroid abuse, though individual responses to treatment vary.
1 citations
,
February 2013 in “Steroids” In this study, a deproteinized bone mineral showed potential to increase DHT production, suggesting an anabolic effect on human periosteal fibroblasts with possible implications for wound healing.