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research Cornified Epithelial Teeth of Jawless Vertebrates Contain Proteins Similar to Keratin-Associated Proteins of Mammalian Skin Appendages
This study reports that KRTAP-like proteins, which resemble keratin-associated proteins found in mammals, are also present in the cornified teeth of various lamprey species, suggesting these proteins may serve similar functions in skin appendages across different vertebrates despite independent evolutionary origins.
research Effects of SLC45A2 and GPNMB on Melanin Deposition Based on Transcriptome Sequencing in Chicken Feather Follicles
In this study, researchers examined chicken feather follicle tissues from differently colored chickens and found that the genes SLC45A2 and GPNMB are involved in promoting melanin deposition, which enriches understanding of the genetic mechanisms affecting feather color.
research Epidermal and Hair Follicle Progenitor Cells Express Melanoma-Associated Chondroitin Sulfate Proteoglycan Core Protein
MCSP may help identify and regulate skin stem cells, affecting hair growth and regeneration.
research Development of Hair Follicle Dermal Papilla Spheroids Encapsulated in Alginate Hydrogel with Extracellular Matrix Protein
This study found that encapsulating dermal papilla spheroids in alginate hydrogel with extracellular matrix proteins increased alkaline phosphatase activity, suggesting an enhanced manipulation of dermal papilla activity.
research Distinct mutations in human basic hair keratins 1 and 6 cause monilethrix: Implications for protein structure and clinical phenotype
research Outer root sheath keratinization in anagen and catagen of the mammalian hair follicle. A seventh distinct type of keratinization in the hair follicle: trichilemmal keratinization.
This study describes trichilemmal keratinization as a distinct process of hair follicle keratinization that occurs in specific areas of the outer root sheath, illustrated using electron microscopy on dog hair.
research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling
This study found that cathepsin L deficiency in mice led to significant abnormalities in hair follicle development and cycling, including disrupted hair shaft outgrowth and premature hair growth phase entry.
research Wedelolactone inhibits breast cancer-induced osteoclastogenesis by decreasing Akt/mTOR signaling
This study found that wedelolactone, a natural compound from plants, inhibited breast cancer-mediated osteoclast differentiation and activity in vitro, suggesting its potential as a therapy for bone destruction in breast cancer bone metastasis.
research Monilethrix unveiled by initial androgenetic alopecia.
This study diagnosed an 11-year-old girl with initial androgenetic alopecia and monilethrix after observing unique hair shaft abnormalities and skin conditions, unlike her affected parents.
research Black Hair Follicular Dysplasia in Black and White Saluki Dogs: Differentiation from Color Mutant Alopecia in the Doberman Pinscher by Microscopic Examination of Hairs
This study observed that black-haired areas in female Saluki puppies developed hypotrichosis, with dilated hair follicles containing melanin clumps, while white-haired areas remained normal.
research C57BL/6 마우스에서 모발성장 관련 효소 활성도 및 유전자 발현 변동
This study found that in a shaving animal model of mice, increased enzyme activities and gene expression correlated with enhanced hair growth, suggesting they are good biomarkers in the anagen phase.
research Conversion of C57Bl/6 mice from a tumor promotion–resistant to a –sensitive phenotype by enhanced ornithine decarboxylase expression
This study reported that overexpressing ornithine decarboxylase in C57Bl/6 mice increased their sensitivity to tumor promotion by TPA, a change reversible by doxycycline treatment.
research Tricholemmoma and tricholemmal carcinoma and Cowden syndrome
This article reviews the characteristics and diagnostic criteria of tricholemmoma and tricholemmal carcinoma, detailing their clinical presentations and associations but reports no new clinical findings.
research Urokinase plasminogen activator (uPA) is a positive regulator of outer root sheath keratinocyte proliferation
This study found that urokinase plasminogen activator (uPA) is elevated in hyperproliferative hair follicle keratinocytes in mice, and its inhibition significantly reduces their proliferation.
research Atrichia with papular lesions resulting from mutations in the rhesus macaque (Macaca mulatta) hairless gene
This study identified a compound heterozygous mutation in a hairless rhesus macaque, which was associated with skin abnormalities similar to those in hairless mice and humans with APL.
research Sequence and Expression of Murine Type I Hair Keratins mHa2 and mHa3
mHa2 and mHa3 keratins have different structures and roles in mouse hair and tongue tissues.
research Expression of Potential Dermal Progenitor Cell Markers in the Tumour and Stroma of Skin Adnexal Malignant and Benign Tumours
This study found that CRABP1, Nestin, and Ephrin B2 are expressed in both the tumor stroma and invasive front of skin adnexal tumors and basal cell carcinomas.
research PHOSPHATIDES IN MOUSE EPIDERMIS UNDERGOING NORMAL AND ABNORMAL GROWTH CHANGES.
This study found no significant differences in phosphatide distribution between normal and cancerous mouse epidermis during different stages of growth, despite variations in total phosphatide levels.
research Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire
This study visualized mitochondrial metabolism in cultured bovine hair follicles and plucked human hairs, finding that ROS and mitochondrial polarization correlate in specific hair follicle regions, particularly near keratin deposition sites.
research Bullous pilomatrixoma: Without a “Shadow” of doubt – Role of ROSE and cytology
This case report documents the presentation and diagnosis of a rare bullous pilomatrixoma in a 20-year-old female using fine needle aspiration cytopathology, highlighting diagnostic challenges and features.
research Solitary, subcutaneous, fixed, firm, and fast-growing nodule
A man had a non-cancerous, fast-growing skin lump on his arm that was removed with surgery.
research White Hair Follicles in Alopecia Areata.
In this study, researchers found that alopecia areata patches with white hair follicles showed a significant decline in Sox10 marker expression compared to patches without white hairs, while other melanocytic markers were similarly expressed in both groups.
research Nestin is a marker of unipotent embryonic and adult progenitors differentiating into an epithelial cell lineage of the hair follicles
This study found that nestin-expressing progenitor cells, capable of becoming ORS keratinocytes, are present in both developing and adult mouse hair follicles.
research Faculty Opinions recommendation of The keratins of the human beard hair medulla: the riddle in the middle.
This study found that both epithelial and hair keratins are expressed in beard hair medulla cells, exhibiting unique patterns and interactions distinct from other hair follicle and epithelial cells.
research Retinoids Modulate MITF: A Novel Mechanism in the Regulation of Melanogenesis
This study identified 92 novel regulators of melanogenesis, highlighting Aldehyde dehydrogenase 1A1 as a potential target for developing new treatments for hyperpigmentation disorders like melasma.
research No evidence for follicular keratinocyte hyperproliferation in acne lesions as compared to autologous healthy hair follicles
This study found no evidence of increased keratinocyte proliferation in acne vulgaris, suggesting that other mechanisms may be responsible for hyperkeratinization in acne pathogenesis.
research Exosomal miR-222-3p derived from dermal papilla cells inhibits melanogenesis in melanocytes by targeting SOX10 in rabbits
This study found that in Rex rabbits, exosomal miR-222-3p from dermal papilla cells suppresses melanogenesis in melanocytes by targeting the SOX10 gene, highlighting a novel mechanism by which exosomes influence melanin production.
research [Immunohistochemical study on the keratin expression in generating rat hair tissues using anti-hair keratin monoclonal antibodies].
This study found that hair germ and epidermal basal cells differ in keratin expressions in rat hair tissues, with hair-specific keratins appearing after the differentiation of each layer.
research MLO‐mediated Ca2+ influx regulates root hair tip growth in Arabidopsis
This study demonstrated that the FER/MLO signaling module regulates calcium dynamics and ROS accumulation in root hair growth, with the constitutively active MLO (faNTA) able to restore normal development and signaling in specific mutant genotypes, highlighting MLO15's role in root hair tip growth regulation.