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This study found that LDE225, a novel Smo antagonist, shows potential as a topical treatment for basal cell carcinoma due to its high affinity binding and effective inhibition of tumor growth in preclinical models.

This review discusses the cell biological characteristics of the outer root sheath of normal human hair follicles and highlights some similarities and differences with trichilemmal tumors, but reports no new results.

This study found that mutant mice with the we/we wal/wal genotype exhibit significant defects in hair shaft structure and epidermis stratification, correlating with postnatal alopecia symptoms.

In this study, crossing mice overexpressing antizyme with MEK mutants significantly delayed tumor development and reduced tumor frequency, likely by slowing cell growth in skin tumors.

This review examines the process of cornification as a mode of programmed cell death and outlines how keratinocytes activate anti-cell death mechanisms to maintain epidermal homeostasis, but reports no new results.

This study in mutant mice found that Bmpr2 and Acvr2a are individually redundant, but together essential for normal hair follicle development, with their reduction causing rapid hair cycling and graying.

This study found that epidermolysis bullosa simplex keratinocytes had impaired mitochondrial activity and more dispersed mitochondrial distribution compared to normal human keratinocytes.

The study suggests that nestin-expressing progenitor cells can differentiate into outer root sheath keratinocytes in hair follicles, indicating distinct progenitors for different hair follicle and epidermal components.

This review highlights the diverse roles of melanocytes in pigmentation, immunity, and hearing among other functions, their involvement in disorders, and their emerging potential in regenerative medicine, including applications in disease modeling and therapy development using advanced technologies.

This study found that mitochondrial fusion regulator Opa1 is crucial for maintaining melanocyte stem cells during the hair follicle cycle in mice, with Opa1 deficiency leading to impaired SCF-KIT signaling, reduced melanocyte populations, and early hair graying.

This study found that CD34- melanocyte stem cells regenerated pigmentation more efficiently, while CD34+ cells showed potential for neuron myelination, suggesting different therapeutic applications for each population.

This article reviews the diverse regulatory roles of alpha-melanocyte-stimulating hormone in skin biology, highlighting its potential involvement in maintaining tissue homeostasis and protecting against inflammation-induced DNA damage but reports no new clinical findings.

Skin cells can help create early hair-like structures in lab cultures.

This study concluded that moderate to severe alopecia in Belgian Blue crossbred calves was due to malabsorption of dietary fat caused by a mixing error of milk replacer.

In this study, three patients with alopecia areata exhibited spotty absence of the whiteness of their nail lunulae, potentially due to defects in the matrical epithelium.

In this study, researchers found that overexpression of CRABP2 enhanced the proliferation of dermal papilla cells in Hu sheep through activation of the Wnt/β-catenin pathway, even when the pathway was inhibited.

This study suggests that Bim and Puma proteins play a role in hair follicle development and maintenance, although they only partially overlap with apoptosis during normal hair cycle stages.

This study found that the cytokeratin patterns in skin epithelia can distinguish between different types, with basal-cell epitheliomas showing a striking similarity to the pilosebaceous tract.

This study observed that the keratinization pattern of trichilemmal cysts in two Japanese women may originate from the proliferation of the outer root sheath in the follicular isthmus of anagen hairs.

The K15 promoter effectively targets stem cells in the hair follicle bulge.

This study found that the Meibomian gland shares structural and cytokeratin composition similarities with hair follicles, and plays a role in hyper-keratinisation observed in obstructive Meibomian gland dysfunction.

This study found that Ber-EP4 immunoreactivity is present in specific areas of hair follicles across different stages of the hair cycle, particularly in the secondary hair germ, but not in mature anagen follicles.

Krox20 is crucial for hair growth and maintaining skin stem cells.

This study suggests that in human osteoblast-like cells, the 5alpha-reductase type 1 isozyme predominantly catalyzes the conversion of testosterone to DHT, which may play a role in bone homeostasis.

This study found that the Wnt pathway activator lithium chloride promotes proliferation and odontoblast differentiation of hair follicle neural crest cells.

In this study, the researchers reported that Krox20 plays a crucial role in epidermal homeostasis and hair development, influencing stem cell maintenance and cell survival through the modulation of cellular pathways.

This study suggests that label-retaining cells in the hair follicle contribute to follicular renewal, indicating a specific role in the hair cycle by proliferating during the late telogen phase.