Lithium Chloride Promotes the Odontoblast Differentiation of Hair Follicle Neural Crest Cells by Activating Wnt/β-Catenin Signaling

    July 2014 in “ Cell Biology International ”
    Tengfei Shan, Cheng Zhou, Rong‐Sen Yang, Fei Yan, Ping Zhang, Yu Fu, Hongbing Jiang
    TLDR Lithium chloride helps hair follicle cells become tooth cells by activating a specific signaling pathway.
    The study investigated the effects of lithium chloride (LiCl) on the differentiation of hair follicle neural crest cells (hf NCCs) into odontoblast-like cells, focusing on the activation of the Wnt/β‐catenin signaling pathway. It was found that LiCl treatment increased the proliferation of hf NCCs and enhanced the expression of β‐catenin in both cytosolic and nuclear compartments. Additionally, pluripotency markers such as Oct4, Klf4, Sox2, and Nanog were more highly expressed in LiCl-treated cells compared to controls. In an in vitro model using dental cell conditioned media, LiCl-treated hf NCCs showed stronger expression of odontoblast markers DSP, DMP1, and Runx2. The results suggested that LiCl could effectively promote the proliferation and odontoblast differentiation of hf NCCs, indicating that chemical approaches like LiCl treatment could be beneficial for developing cell-based therapies.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 13 results

      community Hair follicle neogenesis

       6 upvotes 10 years ago
      A user plans to experiment with creating new hair follicles using methods like derma rolling, applying lithium chloride, tannic acid, and various other substances including caffeine, ketoconazole, and raspberry ketones. They also consider using anti-inflammatories, immunosuppressants, and DHT inhibitors to potentially improve results.

      community Opinions on Scalp fibrosis and DHT?

      in Research/Science  9 upvotes 3 years ago
      The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

      community Microneedling Only Results?? (No fin/minox)

      in Finasteride  4 upvotes 6 years ago
      The post discusses using microneedling alone for hair regrowth without finasteride or minoxidil due to side effects and dependency concerns. The user is also considering the "Zix" formula, acetic acid, topical zinc solutions, and lithium chloride.

      community Genuine Minoxidil Sanity Check-Tiktok Shops

      in Minoxidil  187 upvotes 5 months ago
      A user bought Kirkland Minoxidil from a TikTok shop and sought confirmation of its authenticity through a bleach test, which some users warned could be dangerous. Many participants advised against buying from TikTok due to the risk of fakes, suggesting alternatives like buying from Costco or reputable online pharmacies.

    Related Research

    3 / 3 results