Solitary, Subcutaneous, Fixed, Firm, and Fast-Growing Nodule
May 2022
in “
JAAD case reports
”
TLDR A man had a non-cancerous, fast-growing skin lump on his arm that was removed with surgery.
The document discusses a case of a solitary, subcutaneous, fixed, firm, and fast-growing nodule, ultimately diagnosed as a proliferating pilomatrixoma (aggressive type). This benign variant of pilomatrixoma exhibits atypical features such as basaloid cell pleomorphism, loss of polarity, nuclear hyperchromatism, dermal collagen infiltration, extensive necrosis, and a high mitotic index. The characteristic histopathologic finding for this tumor is the presence of ghost or shadow cells. The recommended treatment is wide local excision with confirmed negative margins to prevent local recurrence. Other treatments like radiotherapy, chemotherapy, and imatinib are not typically necessary.
