Development of Hair Follicle Dermal Papilla Spheroids Encapsulated in Alginate Hydrogel with Extracellular Matrix Protein

November 2024

Phasin Srinualchai, Thanchanok Khorporn, Patsawee Sriboonaied, Peerapat Thongnuek

dermal papilla alginate hydrogel extracellular matrix proteins calcium chloride alkaline phosphatase

TLDR Encapsulating hair follicle cells in a special gel boosts their activity.

The study explored the impact of encapsulating dermal papilla (DP) spheroids in alginate hydrogel combined with extracellular matrix (ECM) proteins on their activity. By aggregating DP cells to mimic their natural spherical structure and introducing them into an alginate solution mixed with ECM, researchers were able to form a hydrogel through crosslinking with calcium chloride. This encapsulation process resulted in elevated alkaline phosphatase (ALP) activity, a molecular marker of DP, indicating that this method can effectively manipulate DP spheroid activity.

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Research cited in this study

research Maintaining Inducibility of Dermal Follicle Cells on Silk Fibroin/Sodium Alginate Scaffold for Enhanced Hair Follicle Regeneration

research Interfollicular Epidermal Stem-Like Cells for the Recreation of the Hair Follicle Epithelial Compartment

research Alginate and Its Application to Tissue Engineering

research Characterization of Human Dermal Papilla Cells in Alginate Spheres

research The Diagnosis and Treatment of Hair and Scalp Diseases

research Assembling Composite Dermal Papilla Spheres with Adipose-Derived Stem Cells to Enhance Hair Follicle Induction

research Strategies to Enhance Epithelial-Mesenchymal Interactions for Human Hair Follicle Bioengineering

research Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration

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