Development of Hair Follicle Dermal Papilla Spheroids Encapsulated in Alginate Hydrogel with Extracellular Matrix Protein

    November 2024
    Phasin Srinualchai, Thanchanok Khorporn, Patsawee Sriboonaied, Peerapat Thongnuek
    TLDR Encapsulating hair follicle cells in a special gel boosts their activity.
    The study explored the impact of encapsulating dermal papilla (DP) spheroids in alginate hydrogel combined with extracellular matrix (ECM) proteins on their activity. By aggregating DP cells to mimic their natural spherical structure and introducing them into an alginate solution mixed with ECM, researchers were able to form a hydrogel through crosslinking with calcium chloride. This encapsulation process resulted in elevated alkaline phosphatase (ALP) activity, a molecular marker of DP, indicating that this method can effectively manipulate DP spheroid activity.
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