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330-360 / 1000+ results![Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist](/images/research/70c5e1a4-a8e1-4369-b8ba-1d07d0b95e15/small/27858.jpg)
research Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist
Clascoterone is a new, effective, and safe acne treatment without systemic side effects.
![A Prospective Study of Cutaneous Adverse Events Induced by Low-Dose Alpha-Interferon Treatment for Malignant Melanoma](/images/research/0bc33b53-3800-453f-b867-ec78b089ea42/small/25053.jpg)
research A Prospective Study of Cutaneous Adverse Events Induced by Low-Dose Alpha-Interferon Treatment for Malignant Melanoma
Most patients treated with low-dose alpha-interferon for malignant melanoma experienced skin side effects, with hair loss being the most frequent.
![Prostate cancer incidence among finasteride and alpha-blocker users in the Finnish Prostate Cancer Screening Trial](/images/research/5df63751-0109-45c9-b2e0-f0f627e4ad2e/small/14957.jpg)
research Prostate cancer incidence among finasteride and alpha-blocker users in the Finnish Prostate Cancer Screening Trial
Finasteride might lower the risk of low-grade prostate cancer but not high-grade cancer, while alpha-blockers might reduce high-grade cancer risk.
![Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Human Alpha Defensin 5 Results in Decreased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissues Devoid of Adnexal Structures](/images/research/5c51a35a-d30f-4c18-96ea-05bc9f99aea0/small/21816.jpg)
research Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Human Alpha Defensin 5 Results in Decreased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissues Devoid of Adnexal Structures
Human alpha defensin 5 helps heal wounds, reduce bacteria, and grow hair on burned skin.
![5-Alpha-Reductase Inhibitors and Combination Therapy](/images/research/e257c8d9-4972-4e68-ae1d-07501a14f22a/small/18415.jpg)
research 5-Alpha-Reductase Inhibitors and Combination Therapy
Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.
![Impact of Alpha Blockers, 5-alpha Reductase Inhibitors and Combination Therapy on Sexual Function](/images/research/a20ec4cb-5f81-4443-bc90-54819d722a3d/small/20273.jpg)
research Impact of Alpha Blockers, 5-alpha Reductase Inhibitors and Combination Therapy on Sexual Function
Medications for enlarged prostate can cause sexual side effects like reduced libido, erectile dysfunction, and ejaculatory problems.
![Effect of alpha lipoic acid on smoking-induced skin damage](/images/research/07c53f43-aad1-4aeb-85a5-a6d397a10d2c/small/27333.jpg)
research Effect of alpha lipoic acid on smoking-induced skin damage
Alpha Lipoic Acid helps protect skin from smoking damage.
![Hair Growth is Promoted in Mouse Dorsal Skin by a Mixture of <i>Platycladus orientalis</i> (L.) Franco Leaf Extract and Alpha-Terpineol by Increasing Growth Factors and wnt3/β-Catenin](/images/research/4012626e-6a41-4f3d-a822-bd4d8a5adf7f/small/22892.jpg)
research Hair Growth is Promoted in Mouse Dorsal Skin by a Mixture of Platycladus orientalis (L.) Franco Leaf Extract and Alpha-Terpineol by Increasing Growth Factors and wnt3/β-Catenin
A mix of Platycladus orientalis leaf extract and alpha-terpineol helps mice grow hair by increasing growth factors and cell growth.
![Analysis of Data From Breast Diseases Treated With 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia](/images/research/2eb4c36c-228a-4dd0-ba26-f6a6a52e17ab/small/13511.jpg)
research Analysis of Data From Breast Diseases Treated With 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia
Medicines for enlarged prostate may raise the risk of breast growth and tenderness but not breast cancer.
research Alpha Blockers and Finasteride for BPH-1996
research MP09-16 5-ALPHA REDUCTASE INHIBITORS FOR MALE LOWER URINARY TRACT SYMPTOMS: A COCHRANE SYSTEMATIC REVIEW AND META-ANALYSIS
5-alpha reductase inhibitors slightly reduce urinary symptoms and may lower surgery and acute retention risks in men.
research 3 alpha, 17 beta-androstanediol glucuronide in plasma. A marker of androgen action in idiopathic hirsutism.
High levels of 3 alpha-diol glucuronide in the blood are a marker of increased androgen action in women with excessive hair growth of unknown cause.
![Structure of human type II 5 alpha-reductase gene.](/images/research/fbfe5710-175b-46df-a180-ed83888622dc/small/21117.jpg)
research Structure of human type II 5 alpha-reductase gene.
The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.
![Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase](/images/research/66e4646f-8129-40fe-84f0-f0d93a41b309/small/21103.jpg)
research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase
New compounds called benzoquinolinones may treat conditions linked to excess DHT.
![Comparison of Finasteride (Proscar®) and Serenoa repens (Permixon®) in the Inhibition of 5-Alpha Reductase in Healthy Male Volunteers](/images/research/ef8de2d3-c1d1-4f19-b7b1-5d6c96f1ad82/small/2024.jpg)
research Comparison of Finasteride (Proscar®) and Serenoa repens (Permixon®) in the Inhibition of 5-Alpha Reductase in Healthy Male Volunteers
Finasteride works better than Permixon in reducing dihydrotestosterone levels.
![Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation](/images/research/e8b94e97-970e-4fc0-b632-deb3fe20de28/small/20304.jpg)
research Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation
5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.
![Finasteride: A slow-binding 5.alpha.-reductase inhibitor](/images/research/4f3ff11d-e70b-4e1a-bc70-d59a185e7d39/small/2004.jpg)
research Finasteride: A slow-binding 5.alpha.-reductase inhibitor
Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
![Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta)](/images/research/3dc213fc-c0b0-4e98-b5a6-4e4244447995/small/2144.jpg)
research Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta)
Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.
![The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.](/images/research/520cc6f5-c6a2-42d1-98f3-aa27af81d816/small/2041.jpg)
research The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.
Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.
research 5 Alpha-reductase inhibitors: whatʼs new?
A new drug, dutasteride, is at least as effective as the older drug, finasteride, for treating enlarged prostate and may have additional uses.
![5-Alpha reductase deficiency](/images/research/170ee7d3-4c59-4976-ae3e-f58031d6a5ea/small/14401.jpg)
research 5-Alpha reductase deficiency
5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.
![Five-alpha-reductase Inhibitors for prostate cancer prevention.](/images/research/86bcbf95-1438-48ac-b088-f42b9e649dda/small/15036.jpg)
research Five-alpha-reductase Inhibitors for prostate cancer prevention.
5-alpha-reductase inhibitors can lower prostate cancer risk but may increase high-grade tumors and cause sexual side effects.
![[Local therapy of androgenetic alopecia with 17 alpha-estradiol. A controlled, randomized double-blind study (author’s transl)].](/images/research/d46b6ef2-0dd1-452c-b46c-144276fed3ff/small/5976.jpg)
research [Local therapy of androgenetic alopecia with 17 alpha-estradiol. A controlled, randomized double-blind study (author’s transl)].
Hair lotions with 17 alpha-estradiol can reduce hair loss but won't regrow new hair.
![5‐alpha‐reductase inhibitors are associated with reduced frequency of COVID‐19 symptoms in males with androgenetic alopecia](/images/research/0b4442cf-4f5f-4be3-abba-5f6f05e25b7a/small/5185.jpg)
research 5‐alpha‐reductase inhibitors are associated with reduced frequency of COVID‐19 symptoms in males with androgenetic alopecia
5-alpha-reductase inhibitors may reduce COVID-19 symptoms in bald males.
![A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome](/images/research/12dccfbf-e3d4-4e57-9ede-4ec950b38c32/small/33100.jpg)
research A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome
The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.
![Side Effects of 5‐Alpha Reductase Inhibitors: A Comprehensive Review](/images/research/68d4e74a-4b26-4fff-a65d-cac0576324ec/small/14498.jpg)
research Side Effects of 5‐Alpha Reductase Inhibitors: A Comprehensive Review
5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.
![Alopecia areata during Interferon Alpha-2b/Ribavirin Therapy](/images/research/ffc62b93-a2ce-4bbe-b820-674e35ef677a/small/25153.jpg)
research Alopecia areata during Interferon Alpha-2b/Ribavirin Therapy
A woman's hair loss during treatment with specific hepatitis C drugs grew back after stopping the medication.
![Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque.](/images/research/723f719f-ebd4-4db8-bcb3-b7435bf55b62/small/1977.jpg)
research Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque.
Finasteride and minoxidil together promote hair growth better than either alone.
![Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome](/images/research/4bcba3bb-4bd2-4e4e-92d9-b1e693c09b16/small/18547.jpg)
research Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome
The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.