Adverse Effects of the 5-Alpha-Reductase Inhibitor Finasteride on Daphnia Magna: Endocrine System and Lipid Metabolism Disruption

    January 2024
    Hyunki Cho, Si-Eun Sung, Giup Jang … Young Jun Kim
    Studysummary This study assessed the environmental impact of the drug finasteride on Daphnia magna, finding that both acute and chronic exposure impaired development and reproduction, affected gene expression and metabolism, and altered lipid profiles, highlighting the need to understand pharmaceutical impacts on aquatic ecosystems.
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    Research cited in this study 5

    1. Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target Journal of Medicinal Chemistry · 2021
    2. Toxicity of the Pharmaceuticals Finasteride and Melengestrol Acetate to Benthic Invertebrates Environmental Science and Pollution Research · 2020
    3. Role of 5α-Dihydrotestosterone in Testicular Development of Gilthead Seabream Following Finasteride Administration The Journal of Steroid Biochemistry and Molecular Biology · 2017
    4. Evaluation of the 5α-Reductase Inhibitor Finasteride on Reproduction and Gonadal Development in Medaka, Oryzias Latipes General and Comparative Endocrinology · 2015
    5. Exposure of Xenopus Laevis Tadpoles to Finasteride, an Inhibitor of 5-Alpha Reductase Activity, Impairs Spermatogenesis and Alters Hypophyseal Feedback Mechanisms Journal of Molecular Endocrinology · 2009

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    4. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992