5-Alpha-Reductase Inhibitors in the Treatment of Male Androgenetic Alopecia: Clinical Experience

September 2024 in “ Health of Man ”

Inessa Serbina, Svitlana Vozianova

5-alpha-reductase inhibitors dutasteride androgenetic alopecia minoxidil hair miniaturization AGA Rogaine

TLDR Low-dose dutasteride effectively and safely promotes hair growth in men with androgenetic alopecia.

This study evaluated the effectiveness and safety of low-dose dutasteride in treating male androgenetic alopecia (AGA) in 35 men aged 20–50 years. Over 12 months, patients received dutasteride and topical minoxidil, resulting in significant hair growth in 68.6% of participants and a reduction in hair shedding in all patients. The treatment reversed hair miniaturization, with 74.3% showing a positive response. While some experienced sexual dysfunction, these side effects resolved without discontinuing the drug. The study concludes that low-dose dutasteride is effective and safe for male AGA, though further research is needed to refine treatment regimens.

View this study on health-man.com.ua →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community SCUBE3 and GT20029 could be the closet thing to a cure: Hair Follicle Regeneration and Protection Against DHT

in Research/Science 15 upvotes 1 year ago

SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.

community Hair Loss Drugs Ranked in Order of Efficacy

in Research/Science 67 upvotes 1 year ago

Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.

community Study shows further evidence that finasteride and dutasteride take 12-18 months or more to show significant results. Do NOT give up early

in Finasteride/Dutasteride 247 upvotes 1 year ago

The conversation discusses the effectiveness of finasteride and dutasteride in treating hair loss, emphasizing that significant results often take 12-18 months or more. Dutasteride is generally considered superior, with similar or fewer side effects than finasteride, but patience is required for noticeable improvement.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 138 upvotes 4 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 485 upvotes 4 months ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Fats on your Head to Stop Hair Loss?

in Research/Science 143 upvotes 10 months ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

Related Research

5 / 5 results

Phytotherapeutic Alternatives to the Use of Finasteride and Dutasteride as 5-Alpha Reductase Inhibitors in the Treatment of Androgenetic Alopecia: A Review

research Phytotherapeutic Alternatives to the Use of Finasteride and Dutasteride as 5-Alpha Reductase Inhibitors in the Treatment of Androgenetic Alopecia: A Review

January 2024 in “Brazilian Journal of Hair Health”

Some plant-based products might treat hair loss with fewer side effects than current medications.

research Combination Therapy with Oral Minoxidil and Dutasteride in the Treatment of Male Patterned Baldness: A Case Report

January 2022 in “Cosmoderma”

Using oral minoxidil and dutasteride together can quickly increase hair growth and volume with minimal side effects.

research What Do We Know About 5-Alpha Reductase Inhibitors?

January 2018 in “Surgical and Cosmetic Dermatology”

5-alpha reductase inhibitors like finasteride and dutasteride are effective for treating enlarged prostate and male pattern hair loss.

research Effective Treatment of Female Androgenic Alopecia with Dutasteride

33 citations, September 2005 in “PubMed”

Dutasteride successfully treated a woman's hair loss when other treatments failed.

research 5 Alpha-Reductase Inhibitors: What's New?

47 citations, January 2003 in “Current opinion in urology”

A new drug, dutasteride, is at least as effective as the older drug, finasteride, for treating enlarged prostate and may have additional uses.