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This study introduces a new multiaxial bioreactor system that uniformly stretches tissue-engineered skin grafts and improves skin tissue maturation through enhanced cellular distribution and environmental monitoring.

In this study, epidermal stem cells were found to enhance blood vessel formation and support successful one-step transplantation of tissue-engineered skin in a rat model.

This study reports that transplantation of an ESCs-collagen-chitin biomimetic membrane leads to successful in situ skin regeneration, including hair follicle cell proliferation and formation of dermatoglyphs, in nude mice with full-thickness skin defects.

Researchers created long-lasting, diverse skin organoids from mouse hair follicle stem cells, useful for studying skin.

In this study, researchers explored the molecular and cellular traits of avian reticulate scales, finding that they lack localized stem cell niches for regeneration, unlike other scale types, leading to repair but not regeneration after wounding.

This study found that bioelectric and biochemical signaling mechanisms coordinate collective cell movement during chicken feather bud morphogenesis, suggesting a potential new angle for research in skin development and wound healing.

This source highlights the challenge in achieving scarless healing with skin appendage regeneration for wounds and notes that vitamin A derivatives show promise for promoting new follicle growth. However, specific results from this research are not reported in the abstract.

This study presents a new long-term 3D skin model using cells from mature donor skin, showing significant features of skin aging, such as decreased cellular proliferation and hyaluronan content.

This study found that the JAK1 inhibitors baricitinib and abrocitinib significantly reduced mechanical alloknesis in a murine model of atopic dermatitis, whereas the JAK2 inhibitor AZ960 had no effect.

This study found that desmosomal adhesion plays a crucial role in epithelial morphogenesis and cell positioning, equivalent in importance to that of adherens junctions.

In this study, the researchers developed a hydrogel mimicking the fetal environment that significantly accelerated wound healing and hair follicle regeneration in vivo, with over 94% wound closure in 14 days, surpassing hydrogels lacking certain additives.

This study found that a skin-like structure can be generated in vitro by implanting early passage hair follicle bulb cells into collagen/chitosan porous scaffolds.

This review summarizes the latest progress and challenges in skin organoid research, emphasizing advancements in organoid construction, applications in disease modeling, and factors affecting tissue maturation, while noting barriers such as vascularization and neural integration that hinder clinical translation.

In this study, a flexible adhesive self-powered wound dressing promoted skin regeneration and reduced inflammation in vivo using sound wave driving, without requiring skin bending or external devices.

Collagen scaffolds in cell therapy can transform skin to be more resilient and pressure-responsive.

This study found that electrospun membranes with aligned surface topography enhanced wound healing and hair follicle regeneration while modulating the immune response in a mouse skin wound model.

This review highlights recent advancements in the engineering of skin organoids using hydrogels, which improve their structural and functional fidelity by supporting the architecture and integration of vascular and neural components, promising to enhance regenerative medicine, drug discovery, and complex skin disorder studies.

This review discusses the origins, differentiation, and function of dermal fibroblasts in skin development and healing, reporting no new clinical results.

This study found that VE-cadherin and Alk1, traditionally linked to vascular functions, also play crucial roles in maintaining nerve homeostasis in mice during hair growth cycles by modulating certain cell populations.

This article discusses a hypothesis on the development and evolution of scales, hairs, and feathers from fish to amniotes, based on regions of dermo-epidermal interactions in skin, but reports no new findings.

This study found that hair regrowth differed by position on mouse dorsal skin, appearing earlier at cranial sites compared to caudal sites, and revealed distinct gene expression profiles between these regions, impacting the design and interpretation of hair-regeneration experiments.

In this study, an injectable alginate hydrogel with Fibronectin3 was developed, demonstrating high biocompatibility and ability to enhance wound healing in mice, suggesting promise for clinical application in treating irregular wounds.

This study demonstrated the potential of epithelial cell scaffolds fabricated with various materials for effective hair regeneration, highlighting their promising application in tissue engineering for alopecia treatment.

This study found that Fraser's Dolphin, a tight-skinned mammal, can regenerate complex skin architecture with minimal scarring after large full-thickness wounds, even in high-tension environments, offering insights into regenerative healing mechanisms typically obscured by fibrotic responses.

This study reports that tissue-engineered skin using ES cell-derived epidermal stem cells and collagen sponge successfully healed full thickness skin defects in mice, forming epidermis and structures resembling glands and hair follicles.

In this study, researchers developed a method using stencils to create controlled stiffness gradients in alginate hydrogels, revealing that stiffer regions within the gels promote deeper invasion by breast cancer cells, facilitating the study of mechanosensitive cellular behaviors.

This study found that mature adipocytes can dedifferentiate into fibroblast-like cells, driven by PDGF and TGFβ signaling, which may play a role in wound repair and fibrosis.

This study reported that a three-dimensional hydrogel culture system supports the growth and maintenance of distinct dermal papilla cell types, crucial for skin reconstitution assays in neonatal mice.

This study revealed that during avian skin development, complex tissue architecture results from specific cellular flows and mechanical processes that guide feather bud protrusion and elongation, with distinct differences noted in scale development, where rigidity restricts such transformations.

This study demonstrated that PEGDA hydrogel microwells successfully supported cell survival and proliferation while mimicking hair follicle architecture in vitro, suggesting a potential tool for hair follicle engineering.