Molecular and Cellular Characterization of Avian Reticulate Scales and the Evolutionary Development of Skin Appendages in Foot Soles

    Tzu-Yu Liu, Michael W. Hughes, Hao Ven Wang … Ping Wu
    Studysummary In this study, researchers explored the molecular and cellular traits of avian reticulate scales, finding that they lack localized stem cell niches for regeneration, unlike other scale types, leading to repair but not regeneration after wounding.
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    Research cited in this study 4

    1. Transient Agonism of the Sonic Hedgehog Pathway Triggers a Permanent Transition of Skin Appendage Fate in the Chicken Embryo Science Advances · 2023
    2. Comprehensive Molecular and Cellular Studies Suggest Avian Scutate Scales Are Secondarily Derived from Feathers, and More Distant from Reptilian Scales Scientific Reports · 2018
    3. Sostdc1 Defines the Size and Number of Skin Appendage Placodes Developmental biology · 2012
    4. Reptile Scale Paradigm: Evo-Devo, Pattern Formation and Regeneration The International Journal of Developmental Biology · 2009

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    1. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989