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Glossary Label-Retaining Cells

cells that divide infrequently and retain DNA labels

Label-Retaining Cells (LRCs) are a type of cell that retains a DNA label over an extended period, indicating they divide infrequently. This characteristic is often used to identify stem cells or progenitor cells in tissues, including hair follicles, as these cells typically divide less frequently than other cell types, allowing them to maintain tissue homeostasis and regeneration.

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Research

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research Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis

421 citations , September 2003 in “Development”

This study concluded that label-retaining cells in mouse epidermis differ in their sensitivity to proliferative stimuli, influencing their division and potential transdifferentiation without consistently depleting their population.

Label Retaining Cells with Myoepithelial Characteristics from the Proximal Acinar Region Define Stem Cells in the Sweat Gland

research Label Retaining Cells (LRCs) with Myoepithelial Characteristic from the Proximal Acinar Region Define Stem Cells in the Sweat Gland

36 citations , September 2013 in “PLoS ONE”

This study found that sweat gland stem cells primarily maintain sweat gland homeostasis but can trans-differentiate to aid in epidermal healing and regenerate diverse skin structures under certain conditions.

research The Localization of Label-Retaining Cells in Eccrine Glands

28 citations , January 2009 in “Journal of Investigative Dermatology”

Stem cells in eccrine glands could be used for regenerative medicine.

research The Localization of Label-Retaining Cells in Mouse Nails

22 citations , October 2007 in “Journal of Investigative Dermatology”

Stem cells in mouse nails are found in the nail matrix and may control nail growth.

Defining the Localization and Molecular Characteristics of Minor Salivary Gland Label-Retaining Cells

research Defining the Localization and Molecular Characteristic of Minor Salivary Gland Label-Retaining Cells

18 citations , April 2014 in “Stem cells”

The researchers reported that minor salivary gland stem cells exhibit stem cell characteristics and respond to tobacco-derived carcinogens, implicating the transforming growth factor beta pathway in their maintenance.

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community I had claude create a protocol only using fda approved drugs.

4 upvotes 8 months ago

A new hair loss protocol using FDA-approved topical treatments targets eight pathways, potentially improving results by 60-75% compared to the standard 40-50% from oral minoxidil and finasteride. The protocol includes minoxidil, finasteride, tacrolimus, cetirizine, bimatoprost, lithium gluconate, losartan, melatonin, NAC, caffeine, and tretinoin, with a monthly cost of $35-50 in Mexico and $80-150 in the US.

community Finally, some real breakthroughs. A comparison of the two leading baldness treatments: PP405 versus ABS-201

106 upvotes 10 months ago

PP405 and ABS-201 are promising treatments for male pattern baldness. PP405 shows rapid hair growth in human trials, while ABS-201 shows significant regrowth in animal studies but is still in early human trials.

community PP405 could be released before GTA 6

in Chat 133 upvotes 9 months ago

PP405 is discussed as a potential hair loss treatment, but its effectiveness and safety are uncertain. Some users express skepticism, while others are hopeful, comparing it to existing treatments like Minoxidil and Finasteride.

community Finasteride vs Dutasteride, something ain’t right.

in Finasteride/Dutasteride 31 upvotes 11 months ago

Finasteride is generally seen as more successful for hair loss than Dutasteride, with fewer negative experiences reported. Dutasteride is considered more effective but often leads to more complaints, possibly due to higher expectations or improper use.

community I don’t understand this, is he equating taking Fin with being on HRT?

303 upvotes 1 year ago

The conversation is about using finasteride and testosterone replacement therapy (TRT) for hair loss and their role in gender-affirming care. It debates whether these treatments are considered hormone replacement therapy (HRT) and their implications for both cisgender and transgender individuals.

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