Long-Lived and Genetically Diverse Skin Organoids Derived from Murine Adult Hair Follicle Stem Cells

July 2025 in “ Journal of Investigative Dermatology ”

Rachel J. Waldemer, , Eve Kandyba, Allan Balmain, Jeroen P. Roose

hair follicle stem cells skin organoids 3D skin models hair follicle-associated markers skin homeostasis skin regeneration skin pathology

TLDR Researchers created long-lasting, diverse skin organoids from mouse hair follicle stem cells, useful for studying skin.

Researchers have developed long-lived and genetically diverse skin organoids from adult murine hair follicle stem cells, overcoming limitations of existing 3D skin models. These organoids, derived from adult and elderly mice, can be viably frozen, thawed, and passaged over 20 times while maintaining culture for more than 3 months. They express hair follicle-associated markers and originate from three distinct hair follicle stem cell populations. This novel method allows for the creation of skin organoids that retain hair follicle stem cell markers and can be biobanked, providing a valuable resource for studying skin homeostasis, regeneration, and pathology.

View this study on jidonline.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community JW Pharmaceutical shows superiority of 'JW0061' in hair growth over existing treatments in US

in Research/Science 99 upvotes 1 year ago

JW0061 shows superior hair growth results compared to existing treatments, with significant increases in hair follicles. The Wnt/β-catenin pathway is crucial for hair growth, and JW0061 activates this pathway effectively.

community Target Area Hair Count (TAHC) increase comparasion of all future treatments in clinical trial phases

in Research/Science 35 upvotes 1 year ago

Finasteride, Minoxidil, Bioneer CosmeRNA, Technoderma, Kintor, Hope, Breezula, and Follicum treatments showed increases in hair count, with Technoderma showing the highest increase at 24.3 hairs/cm². Amplifica has not yet published results.

community Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results

in Update 415 upvotes 11 months ago

ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.

community Why isn’t anyone talking about this?

in Research/Science 29 upvotes 1 year ago

Hair cloning is being developed by companies like Kangstem Biotech and Stemson, with potential availability in a few years. Initial costs are expected to be high, but prices may decrease over time.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 92 upvotes 3 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

Similar Research

6 / 1000+ results

research Bioengineered Skin Organoids: From Development to Applications

August 2023 in “Military Medical Research”

Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.

research Organoids in Skin Wound Healing

November 2024 in “Burns & Trauma”

Skin organoids help improve wound healing and tissue repair.

research In Vitro and Ex Vivo Hair Follicle Models to Explore Therapeutic Options for Hair Regeneration

1 citations , January 2022 in “Stem cell biology and regenerative medicine”

New methods to test hair growth treatments have been developed.

research Generation of Human-Induced Pluripotent Stem Cell-Derived Adherent 3-Dimensional Skin Hair-Follicle Organoids

2 citations , September 2022 in “Organoid”

A new method was developed to efficiently grow skin hair follicles from stem cells, potentially aiding alopecia treatment.

research Proceedings of the Ninth World Congress for Hair Research 2015

January 2017 in “Journal of Investigative Dermatology Symposium Proceedings”

The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.

research Modeling of Solar UV-Induced Photodamage on the Hair Follicles in Human Skin Organoids

January 2024 in “Journal of tissue engineering”

Sunlight exposure damages hair follicles, but certain stem cell-derived particles can reduce this damage and help with hair regeneration.