Jak1 Signaling Is Involved in the Induction of Mechanical Alloknesis in Atopic Dermatitis

This study explored the role of JAK1 signaling in mechanical alloknesis (m-alloknesis) in atopic dermatitis (AD) using a murine model. It found that JAK1-selective inhibitors, such as abrocitinib, and JAK1/2 inhibitors, like baricitinib, significantly reduced m-alloknesis scores without affecting skin barrier integrity or dermatitis severity. The study involved 8 mice per group and demonstrated that JAK1 signaling is crucial for m-alloknesis induction in AD. These findings suggest that selective JAK1 inhibition could be a promising therapeutic strategy to alleviate m-alloknesis and improve the quality of life for AD patients, independent of general skin inflammation and barrier function.