Jak1 Signaling Is Involved in the Induction of Mechanical Alloknesis in Atopic Dermatitis

    November 2025 in “ Biomedicines ”
    Ying Zuo, Sumika Toyama, Motoki Morita, Qiaofeng Zhao, Eriko Komiya, Soichiro Yoshikawa, Mitsutoshi Tominaga, Kenji Takamori
    TLDR JAK1 inhibitors can help reduce itchiness in atopic dermatitis.
    This study explored the role of JAK1 signaling in mechanical alloknesis (m-alloknesis) in atopic dermatitis (AD) using a murine model. It found that JAK1-selective inhibitors, such as abrocitinib, and JAK1/2 inhibitors, like baricitinib, significantly reduced m-alloknesis scores without affecting skin barrier integrity or dermatitis severity. The study involved 8 mice per group and demonstrated that JAK1 signaling is crucial for m-alloknesis induction in AD. These findings suggest that selective JAK1 inhibition could be a promising therapeutic strategy to alleviate m-alloknesis and improve the quality of life for AD patients, independent of general skin inflammation and barrier function.
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