Skin Organoids for Disease Modeling, Drug Screening, and Regenerative Medicine: Recent Advances and Future Perspectives

    January 2026 in “ Wound Repair and Regeneration ”
    D. G. Wang, Manzoor Majid, Jiani Chen, Chunjie Wu, Yuzong CHEN, Feng Ni
    Studysummary This review summarizes the latest progress and challenges in skin organoid research, emphasizing advancements in organoid construction, applications in disease modeling, and factors affecting tissue maturation, while noting barriers such as vascularization and neural integration that hinder clinical translation.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    This review article discusses the recent advancements and future perspectives of skin organoids, which are 3D multicellular systems used for disease modeling, drug screening, and regenerative medicine. The authors highlight the construction of skin organoids, focusing on the integration of epidermis, dermis, basement membrane units, and accessory organs like hair follicles and sweat glands. Key challenges include improving vascularization, neurogenesis, and immune integration. The review emphasizes the potential of skin organoids in modeling various conditions such as inflammation, genetic disorders, infections, and tumors, which aids in drug discovery and toxicology assessment. The authors propose a validation pathway that integrates engineering, biology, and regulatory considerations to enhance the transition from research prototypes to clinical applications, suggesting the use of multi-omics, chemoproteomics, and artificial intelligence for optimization.
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