March 2024 in “The journal of sexual medicine” This case study observed that in four middle-aged men with ejaculation disorders, therapy with human chorionic gonadotropin (hCG) alone or combined with recombinant follicle-stimulating hormone (rFSH) improved sexual desire, semen volume, and various other symptoms, although some experienced elevated estradiol levels and hair loss.
November 2023 in “Curēus” This study, conducted in Jeddah, Saudi Arabia, found that women with PCOS who consumed diets high in carbohydrates, fats, and refined sugars had a significant prevalence of obesity and struggled with weight loss, with fast food consumption notably associated with facial acne.
September 2023 in “Journal of the American Academy of Dermatology” December 2022 in “Laboratory Animal Research” This study described two cases of trichoblastomas in the tactile hair skin of aged house musk shrews, highlighting that their histological structure differs from that in humans and other animals.
April 2021 in “Han'gug miyong haghoeji/Journal of the Korean society of cosmetology” This study found that consuming raw cheonggukjang improved various measures of scalp hair condition in middle-aged women over a 12-week period.
May 2020 in “Hair transplant forum international” This study found that, among Indian men aged 50-55 with androgenetic alopecia, 78% of occipital donor areas fitted standard safe donor area criteria, but 22% did not, indicating a need for tailored selection in hair transplants.
January 2018 in “Journal of translational science” In this study, oral broccoli sprouts intake did not affect plasma androgen levels in males, while alfalfa sprouts intake increased testosterone and DHT levels, which may help prevent male late onset hypogonadism.
This study found that in mice, type XVII collagen is essential for controlling epidermal cell proliferation through Wnt signaling, with its deficiency or altered distribution leading to skin hyperproliferation and aging-like changes.
May 2017 in “Endocrine Abstracts” This study found that in HIV-infected men, erectile dysfunction was influenced by the duration of HIV infection but not associated with serum testosterone or HAART therapy.
June 1995 in “International Journal of Gynecology & Obstetrics” Long-term use of oral contraceptives, especially starting before age 20, may increase the risk of early-onset breast cancer.
May 2020 in “Journal of Asian Medical Students' Association” This study concluded that psychological well-being and self-image among Filipino males with androgenetic alopecia may be influenced by age, education level, and disease severity.
70 citations
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November 2013 in “The BMJ” This study observed a temporal association between tamsulosin use for benign prostatic hyperplasia and an increased risk of severe hypotension requiring hospital admission during the first eight weeks of treatment initiation and restart.
34 citations
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September 2013 in “Urology” Long-term use of a certain medication can worsen erectile function in aged rats by damaging penile muscle cells.
14 citations
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March 2018 in “Translational Stroke Research” In this animal study, researchers found that finasteride may offer neuroprotective benefits as a post-ischemic treatment for strokes in aged male rats, suggesting its potential as a therapeutic agent in this context.
12 citations
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May 2024 in “Chemosphere” 6 citations
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February 2022 in “European journal of endocrinology” This study developed a validated method using UPLC-MS/MS to analyze 37 hormones in human hair, enabling broader hormonal profiling for identifying endocrine disorders.
5 citations
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February 2025 in “Pediatric Dermatology” In this study, ritlecitinib was generally well tolerated in pediatric alopecia areata patients aged 6 to <12 years, with no severe or serious adverse events reported, and the drug's pharmacokinetic parameters were successfully characterized.
1 citations
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January 2025 in “Neuropsychopharmacology Reports” In this study, researchers found a direct link between autism and the intake of sugar and maltose, while an inverse connection was observed with the intake of total carbohydrate, fructose, and lactose, indicating a potential relationship between dietary patterns and autism.
This study found that enhancing quercetin bioavailability with EubioQuercetin significantly improved external aging signs in mice and influenced gut microbiota and intestinal gene expression, suggesting potential modulation through the gut microbiota–intestinal barrier axis.
April 2026 in “Preprints.org” The study found that enhancing quercetin bioavailability with EubioQuercetin may amplify its anti-aging effects in mice by modulating the gut microbiota and improving intestinal barrier function.
March 2026 in “International Journal of Homoeopathic Sciences” In this study, 10.25% of school children aged 5-15 in Belagavi were found to have premature greying of hair, with the majority showing mild severity according to the Graying Severity Score.
February 2026 in “Frontiers in Public Health” This study identified that while the overall burden of AA among adolescents and young adults globally continues to rise, the age-standardized rates have slightly decreased, with notable disparities across age, gender, region, and socioeconomic status.
February 2026 in “Clinical Cosmetic and Investigational Dermatology” This study found that while the global incidence of alopecia areata in individuals aged 0–19 declined from 1990-2021, the total number of cases rose, with higher burdens among females, adolescents, and low-SDI populations, particularly in Central Sub-Saharan Africa; disparities suggest a need for targeted interventions.
In this study, PDLLA treatment in middle-aged mice was observed to enhance hair growth by increasing macrophage M2 polarization and hair follicle stem cell proliferation, potentially rejuvenating the skin's microenvironment and offering a novel approach for age-related hair loss.
December 2025 in “PLoS ONE” In this study, among Chinese infants and young children aged 0-5 years, Type II and Type III frontal hairline patterns were the most common, with a negative correlation observed between age and hairline type.
December 2025 in “Actas Dermo-Sifiliográficas” This review analyzes the mechanism and evidence supporting the approved use of ritlecitinib, a JAK3/TEC kinase inhibitor, for treating severe alopecia areata in patients aged 12 and older, highlighting its role in the changing therapeutic landscape of this immune-mediated disease.
November 2025 in “The Journal of Medical Sciences” This article reviews the potential and limitations of cryotherapy for alopecia areata in middle-aged patients and highlights the need for further research, without reporting new clinical findings.
June 2025 in “Acta Dermato Venereologica” This study observed no significant relationship between androgenetic alopecia and psychosocial or sexual symptoms among men aged 33 to 35 in the Northern Finland Birth Cohort 1986, challenging previous findings of such associations.
September 2024 in “Texila international journal of public health” In this study at Sree Balaji Medical College and Hospital, researchers evaluated clinical biomarkers in adolescent and middle-aged women, finding significant differences in SHBG, AMH, and insulin levels between groups, which suggests compensatory hyperinsulinemia may contribute to PCOS development.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed that extracellular matrix scaffold membranes performed less effectively in wound healing for aged mice compared to younger ones, with senescent SPP1+ macrophages potentially hindering epidermal and fibroblast repair abilities.