Evaluating Effect of HCG and HCG+RFSH Therapy on Ejaculation Disorders in Middle-Aged Men: A Case Study

    Hideyuki Kobayashi, Masataka Uetani, Koichi Nakajima, Kōichi Nagao, Nazrul Islam
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    Studysummary This case study observed that in four middle-aged men with ejaculation disorders, therapy with human chorionic gonadotropin (hCG) alone or combined with recombinant follicle-stimulating hormone (rFSH) improved sexual desire, semen volume, and various other symptoms, although some experienced elevated estradiol levels and hair loss.
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    This case study evaluated the effects of hCG and hCG+rFSH therapy on ejaculation disorders in four middle-aged men (aged 55-59). The therapies aimed to address low semen volume and decreased ejaculatory pleasure. One patient received hCG+rFSH, while three received hCG alone. Results showed increased testosterone levels and improved sexual function across all patients, with some experiencing elevated estradiol (E2) levels managed by adding anastrozole. Notable improvements included increased semen volume, enhanced libido, and better glycemic control in a diabetic patient. Side effects included hair loss in one patient. Overall, the therapies were effective in improving symptoms of ejaculation disorders.
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