12 citations
,
January 2022 in “Cells” This study found that early passage dermal papilla cell-derived extracellular vesicles, combined with specialized medium, helped adipose-derived stem cells develop dermal papilla-like properties.
7 citations
,
March 2017 in “Medical Hypotheses” This study suggests that dysfunctions and altered expression of aquaporins may play a role in PCOS-related disorders, potentially impacting folliculogenesis and integrating with the insulin-dependent hypothesis of PCOS pathogenesis.
3 citations
,
March 2017 in “Regulatory toxicology and pharmacology” In this study, aleglitazar and its metabolite M6 were evaluated for safety in non-clinical settings, revealing organ-targeting effects common to PPAR agonists but no significant tumor increase in rat carcinogenicity studies, supporting progression to Phase 3 clinical trials.
January 2026 in “Archive ouverte UNIGE (University of Geneva)” This narrative review examined skin-sparing techniques in gynecomastia surgery and found satisfactory thoracic remodeling with acceptable morbidity and reduced scarring, but acknowledged methodological differences that limit decisive conclusions.
October 2025 in “Biomolecules” This study found that prolonged intermittent fasting in diet-induced obese mice led to increased levels of inositol monophosphates in white adipose tissue, improved insulin sensitivity, and reduced body weight and fat mass, suggesting a novel metabolic adaptation mechanism.
January 2023 in “Springer eBooks” Using one's own blood platelets and fat can improve facial and hair appearance without surgery.
60 citations
,
January 2023 in “Biogerontology” This review examines testosterone's role in male health and aging but reports no new clinical results; the authors highlight the need for further research on optimal testosterone levels to prevent age-related conditions.
387 citations
,
May 2019 in “International Journal of Molecular Sciences” This review discusses the therapeutic potential of adipose-derived stem cells compared to other mesenchymal stem cells, emphasizing their promise in treating neurodegenerative, cardiovascular, and autoimmune diseases, but reports no new clinical results.
42 citations
,
May 2016 in “Annual Review of Cell and Developmental Biology” This review explores the novel roles of white adipose tissue in tissue homeostasis and regeneration, emphasizing its impact on epithelial, muscle, and immune tissues, and reports no new clinical results.
29 citations
,
January 2021 in “Journal of Investigative Dermatology” This study demonstrates that dermal white adipose tissue regulates human hair growth and pigmentation through hepatocyte growth factor secretion, highlighting potential therapeutic targets for hair-related disorders.
25 citations
,
June 2013 in “Obesity Reviews” This review examines mesotherapy for local fat reduction, detailing its mechanisms, safety concerns, and the need for research toward FDA-approved uses, but reports no new clinical findings.
24 citations
,
May 2022 in “Frontiers in Endocrinology” This review explores the therapeutic potential of brown adipose tissue for treating polycystic ovary syndrome and reports no new experimental results, emphasizing the need for future research to develop effective strategies.
1 citations
,
January 2024 in “Skin research and technology” This study reviewed various lipolytic agents for reducing submental fat and highlighted that while deoxycholic acid is FDA-approved, other compounds like phosphatidylcholine with deoxycholate lack cosmetic approval due to safety concerns. Understanding these agents' mechanisms and anatomy is crucial for safe fat reduction applications.
August 2023 in “MOJ women's health” This review discusses the potential role of brown adipose tissue in managing polycystic ovary syndrome and reports no new clinical results; it highlights a need for further research on this therapeutic avenue.
21 citations
,
March 2018 in “Experimental Dermatology” This practical guide introduces methods to study human dermal white adipose tissue but does not report new clinical results, emphasizing available techniques and staining protocols.
30 citations
,
December 2018 in “Trends in Endocrinology and Metabolism” The authors concluded that dermal white adipose tissue, influenced by factors like light irradiation, plays a significant role in modulating hair follicle cycles and could be targeted for hair growth treatments.
5 citations
,
October 2021 in “Frontiers in Cell and Developmental Biology” This study examined aging hair follicle stem cells in mice and found that inflammation reduction in dermal white adipose tissue can stimulate regenerative behavior, highlighting its role in hair follicle aging.
3 citations
,
September 2024 in “The FASEB Journal” This review discusses the roles of dermal white adipose tissue in skin functions and pathology, underscoring its antibacterial activity and potential anti-fibrotic role, but reports no new experimental results.
2 citations
,
June 2024 in “Frontiers in Immunology” In this study, researchers developed a 3D in-vitro system for generating functional AT-resident macrophages without cell sorting, providing a valuable tool to study their differentiation and function in various physiological and pathological conditions.
September 2025 in “Development” In this study, deleting the transcriptional pause factor Nelfb in mouse preadipocyte lineages led to defective dermal fat formation and lethal outcomes, while interventions targeting Pparg could rescue adipocyte differentiation and promote dermal white adipose tissue formation, underscoring Nelfb's critical role in adipogenesis.
August 2024 in “Qucosa (Saxon State and University Library Dresden)” In this study on mice, researchers observed that dermal white adipose tissue (dWAT) plays a key role in regulating skin inflammation and tissue repair; however, reduced expression of certain cytokines in obese mice may hinder these processes, indicating potential metabolic disruptions in dWAT during inflammation.
2 citations
,
July 2024 in “International Journal of Molecular Sciences” This review examines the role of adipose-derived stem cells in cancer treatment, particularly for hepatocellular carcinoma, and reports mixed preclinical and clinical findings, underscoring the need for further research.
November 2019 in “Клітинна та органна трансплантологія” This review discusses the functional properties and clinical applications of adipose-derived stem cells in aesthetic medicine and dermatology, but it reports no new clinical results.
9 citations
,
June 2020 in “Cell stem cell” This study found that dermal adipocytes contribute to efficient skin repair by releasing fatty acids that recruit macrophages and transforming into myofibroblasts that aid wound healing.
April 2026 in “Journal of Aesthetic Medicine” This study found that the MIRA technique, using ultrasound-guided needle adjustments, improved cellulite treatment outcomes compared to standard methods in women with stage 3 cellulite, evidenced by greater reductions in adipose thickness and other skin irregularities, along with higher patient satisfaction.
March 2026 in “Preprints.org” This study found that the MIRA technique, which customizes needle length and injection angle guided by ultrasound, improved structural and esthetic outcomes for cellulite treatment compared to standard methods.
October 2025 in “International Journal of Molecular Sciences” This study found that topical rebamipide, originally a gastric ulcer medication, can activate hair follicle stem cells and promote hair regeneration by modulating dermal adipocyte metabolism, with potential targeting of the prostaglandin E receptor EP4.
44 citations
,
June 2023 in “Cell Reports” This study investigated dermal fibroblasts in mouse skin using single-cell RNA sequencing and identified signaling pathways that influence adipogenesis, finding that IL-1-NF-κB promotes, while WNT-β-catenin inhibits, the adipogenic potential of these cells, with implications for wound healing and scar formation.
18 citations
,
October 2021 in “Frontiers in Physiology” This review summarizes recent research on the molecular properties and functions of L-PGDS and PGD2, but reports no new findings, highlighting their pathophysiological roles and guiding future studies.
3 citations
,
March 2023 in “Life” This review discusses recent findings on wound healing with a focus on adipose tissue biology and obesity, but presents no new clinical results.