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The document explains the difficulty in diagnosing and treating brain diseases caused by the immune system and stresses the need for quick and accurate tests.

Long COVID causes various long-term health issues and needs better awareness and treatment.

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Activating TSPO helps protect the retina from damage caused by high eye pressure in glaucoma.

Get head MRI for babies with achondroplasia early, use free immunoglobulin light chains to detect certain neurodevelopmental disorders, and video calls work for speech therapy in patients with facial anomalies.

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

Hair loss can indicate brain aging and potential small vessel disease, but more research is needed to understand the clinical impact.

Manage women's cholesterol with diet, exercise, and careful treatment choices, especially during pregnancy, PCOS, and menopause.

Tissue-specific variation in mutant load complicates genetic counseling and prenatal diagnosis.

Covers common skin issues in kids, their diagnosis, treatment, and need for specialist care.

Hormonal changes and conditions like polycystic ovarian syndrome are major causes of adult acne in women, with varying prevalence among different ethnicities.

Chronic stress in mice changes skin metabolism and gene expression, leading to hair loss.

Altered retinoid metabolism in cicatricial alopecia suggests a balanced vitamin A diet may prevent the condition.

Adrenal disorders can cause lasting brain and behavior issues in children.

Parkinson's disease is linked to skin disorders and skin cells help in studying the disease.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

The HtrA1L364P mutation causes brain dysfunction and blood vessel damage.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Using rodents for research shows that health problems in the womb can cause diseases later in life.

Finasteride may protect brain and improve behavior in rats with liver failure.

Light therapy on the brain shows promise for treating brain diseases and improving brain function.

The circadian clock plays a key role in hair growth and its disruption can affect hair regeneration.

Testosterone therapy may slightly increase sexual desire in women with HSDD but lacks broad recommendation due to safety concerns and limited approval.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

Neuroimaging suggests that treatments targeting brain steroids could help control epilepsy, especially types linked to the menstrual cycle.

Ring Chromosome 11 may be linked to conditions like early puberty, excessive hair growth, hair loss, and type 2 diabetes.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.