Research Progress of Post-Acute Sequelae After SARS-CoV-2 Infection

April 2024 in “ Cell death and disease ”

Taiwei Jiao, Yu‐Ling Huang, Haiyan Sun, Lina Yang

TLDR Long COVID causes various long-term health issues and needs better awareness and treatment.

The article reviews the long-term complications and sequelae, known as Post-acute sequelae after SARS-CoV-2 infection (PASC) or "long COVID" syndrome, which have emerged as a significant global health issue following the acute phase of COVID-19. It highlights the heterogeneity of PASC, affecting multiple organ systems, and discusses the pathophysiological mechanisms, diagnosis, and treatment options. The aim is to raise awareness and improve management strategies for PASC.

View this study on nature.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research More Than 50 Long-Term Effects of COVID-19: A Systematic Review and Meta-Analysis

1250 citations, August 2021 in “Scientific Reports”

COVID-19 leaves 80% of patients with long-term symptoms like fatigue and headaches.

research Telogen Effluvium After SARS-CoV-2 Infection: A Series of Cases and Possible Pathogenetic Mechanisms

28 citations, January 2021 in “Skin appendage disorders”

COVID-19 may cause early hair loss similar to classic temporary hair loss, with further research needed.

research Dermatologic Manifestations of COVID-19: A Comprehensive Systematic Review

27 citations, November 2020 in “International Journal of Dermatology”

COVID-19 can cause skin issues like chilblains and rashes, which may help in early detection, especially in patients without other symptoms.

research Post-Discharge Persistent Symptoms and Health-Related Quality of Life After Hospitalization for COVID-19

737 citations, August 2020 in “Journal of Infection”

Many COVID-19 survivors experience long-term symptoms but still report satisfactory quality of life and return to work.